Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.
Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–2 of 2 results
Advanced filters: Author: Nelo Rivera Clear advanced filters

  • An iron-catalysed method for the direct 3H labelling of pharmaceuticals by hydrogen isotope exchange using tritium gas is reported; the site selectivity of the iron catalyst is orthogonal to currently used iridium catalysts and allows isotopic labelling of complementary positions in drug molecules.

    • Renyuan Pony Yu
    • David Hesk
    • Paul J. Chirik
    Research
    Nature
    Volume: 529, P: 195-199

  • Leveraging enzymatic selectivity, a single reaction stream provides a single diastereomer of the cyclic dinucleotide MK-1454, a promising immune-oncology drug candidate, without the use of protecting groups or chiral auxiliaries.

    • John A. McIntosh
    • Zhijian Liu
    • Matthew L. Maddess
    Research
    Nature
    Volume: 603, P: 439-444