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Showing 1–3 of 3 results
Advanced filters: Author: Nerissa T. Williams Clear advanced filters

  • Promising results of cancer therapies in transplant tumor models often fail to predict efficacy in clinical trials. Here the authors show that, while transplant tumors are cured by radiotherapy and PD-1 blockade, autochthonous sarcomas are resistant to the identical treatment, recapitulating the immune landscape and resistance to checkpoint blockade observed in most sarcoma patients.

    • Amy J. Wisdom
    • Yvonne M. Mowery
    • David G. Kirsch
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • p53 can be activated by oncogenic stress to suppress tumourigenesis, but its role in radiation carcinogenesis has not been studied in p53 wild-type mice. Here, Lee et al. show that knocking down p53 during total-body irradiation not only reduces acute toxicity, but prevents the formation of radiation-induced lymphoma.

    • Chang-Lung Lee
    • Katherine D. Castle
    • David G. Kirsch
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • Using primary mouse model of soft-tissue sarcoma (STS), authors show that sarcoma switches to glutamine metabolism post radiation therapy, and inhibition of glutaminolysis, either via genetic or pharmacological alterations, radiosensitizes STS in vivo.

    • Rutulkumar Patel
    • Daniel E. Cooper
    • David G. Kirsch
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-14