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Showing 1–4 of 4 results
Advanced filters: Author: Netanel Loyfer Clear advanced filters

  • DNA methylation drives parental expression differences at imprinted genes. Here, the authors uncover hundreds of ubiquitous and tissue-specific differentially methylated regions, offering insights into parental regulation and disease inheritance.

    • Jonathan Rosenski
    • Ayelet Peretz
    • Tommy Kaplan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • We describe a human DNA methylome atlas based on deep whole-genome bisulfite sequencing, allowing fragment-level analysis of cell-type-specific markers and providing an essential resource for studies of gene regulation and for deconvolution of cell mixtures and liquid biopsies.

    • Netanel Loyfer
    • Judith Magenheim
    • Tommy Kaplan
    ResearchOpen Access
    Nature
    Volume: 613, P: 355-364

  • Ectopic transcription factor expression can reprogram mouse fibroblasts to pluripotent or trophoblast stem cells. Here the authors apply multi-omics analyses to the induction of pluripotency and trophoblast stem cell state from fibroblasts, comparing these with the changes in transcriptome of early embryonic cells.

    • Mohammad Jaber
    • Ahmed Radwan
    • Yosef Buganim
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell types, and find that cfDNA from patients reveals tissue contributions that agree with clinical findings.

    • Joshua Moss
    • Judith Magenheim
    • Yuval Dor
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12