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The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Chaib et al. find that therapy-induced senescent cells have high programmed cell death 1 ligand 2 (PD-L2), contributing to recurrence. They show that PD-L2 blocking combined with chemotherapy is therapeutically beneficial because it reduces senescent cells and immunosuppressive cell recruitment.

Selim Chaib
José Alberto López-Domínguez
Manuel Serrano
ResearchOpen Access24 Jan 2024
Nature Cancer

Volume: 5, P: 448-462
Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype

Iron is shown to have a central role in senescence, both by triggering senescence and through its accumulation in senescent cells, which is driving the senescence-associated secretory phenotype and, in turn, promotes fibrogenesis.

Mate Maus
Vanessa López-Polo
Manuel Serrano
ResearchOpen Access14 Dec 2023
Nature Metabolism

Volume: 5, P: 2111-2130
Vitamin B₁₂ is a limiting factor for induced cellular plasticity and tissue repair

Kovatcheva et al. show that vitamin B₁₂ improves the efficiency of in vivo reprogramming and tissue repair through its functions in one-carbon metabolism and epigenetic modulation.

Marta Kovatcheva
Elena Melendez
Manuel Serrano
ResearchOpen Access16 Nov 2023
Nature Metabolism

Volume: 5, P: 1911-1930
Identification and characterization of Cardiac Glycosides as senolytic compounds

Senolytic compounds have the ability to eliminate senescent cells from tissues and have been shown to be beneficial in various animal models of age-related diseases. Here the authors show that cardiac glycosides commonly used for heart diseases have senolytic properties in humanized mouse models of tumorigenesis and lung fibrosis.

Francisco Triana-Martínez
Pilar Picallos-Rabina
Manuel Collado
ResearchOpen Access21 Oct 2019
Nature Communications

Volume: 10, P: 1-12
Targeting lymphoid-derived IL-17 signaling to delay skin aging

Solá, Mereu and colleagues describe a chronic inflammatory state in the aging mouse skin that is characterized by IL-17 production by dermal lymphoid cells and demonstrate the potential of inhibition of IL-17 signaling in protection against skin aging.

Paloma Solá
Elisabetta Mereu
Salvador Aznar Benitah
ResearchOpen Access08 Jun 2023
Nature Aging

Volume: 3, P: 688-704
Dietary palmitic acid promotes a prometastatic memory via Schwann cells

Palmitic acid induces stable transcriptional and chromatin changes that lead to long-term stimulation of metastasis in orthotopic models of cancer through the secretion by tumour-associated Schwann cells of a specialized proregenerative extracellular matrix, the ablation of which inhibits metastasis initiation.

Gloria Pascual
Diana Domínguez
Salvador Aznar Benitah
Research10 Nov 2021
Nature

Volume: 599, P: 485-490
Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours

Avgustinova et al. report that targeting the H3K9 methyltransferase G9a in skin cancer does not affect single nucleotide variant profiles, but leads to increased tumour aggressiveness after a prolonged latency.

Alexandra Avgustinova
Aikaterini Symeonidi
Salvador Aznar Benitah
Research19 Nov 2018
Nature Cell Biology

Volume: 20, P: 1400-1409
Targeting metastasis-initiating cells through the fatty acid receptor CD36

Human oral carcinoma cells expressing high levels of the fatty acid receptor CD36 initiate metastasis in mouse models, and metastasis is increased by palmitic acid or a fatty diet and decreased by blockade of CD36.

Gloria Pascual
Alexandra Avgustinova
Salvador Aznar Benitah
Research07 Dec 2016
Nature

Volume: 541, P: 41-45
Author Correction: Identification and characterization of Cardiac Glycosides as senolytic compounds

Francisco Triana-Martínez
Pilar Picallos-Rabina
Manuel Collado
Amendments and CorrectionsOpen Access16 Sept 2020
Nature Communications

Volume: 11, P: 1
Pharmacological inhibition of the CCL2-CCR2 axis fails to reduce inflammation in a rat model of acute lung injury

Marta Camprubí-Rimblas
Neus Tantinyà
Raquel Guillamat-Prats
ResearchOpen Access26 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
Functional brain abnormalities in post COVID-19 condition and their relationship with cognition

Lourdes Carreras-Vidal
Laura Pacheco-Jaime
Bàrbara Segura
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-12

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