tRNAs contain many chemical modifications that regulate their function. Integrating smFRET and cryo-EM approaches, this work demonstrates that m1G37 in tRNAProL stabilizes its conformation in the ribosomal P site in a manner that suppresses mRNA frameshifting and ensures translation fidelity.
- Evelyn M. Kimbrough
- Ha An Nguyen
- Christine M. Dunham
