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Showing 1–8 of 8 results
Advanced filters: Author: Nezar Abdennur Clear advanced filters

  • The authors find that silent chromatin is more diverse than just facultative and constitutive heterochromatin. These inactive types have distinct three-dimensional interaction characteristics that are transposable if the underlying chromatin state is altered.

    • George Spracklin
    • Nezar Abdennur
    • Job Dekker
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 38-51

  • Depletion of chromosome-associated cohesin leads to loss of topologically associating domains in interphase chromosomes, without affecting segregation into compartments, and instead, it unmasks a finer compartment structure that reflects local chromatin and transcriptional activity.

    • Wibke Schwarzer
    • Nezar Abdennur
    • Francois Spitz
    Research
    Nature
    Volume: 551, P: 51-56

  • This paper describes the ‘4DN Data Portal’ that hosts data generated by the 4D Nucleome network, including Hi-C and other chromatin conformation capture assays, as well as various sequencing-based and imaging-based assays. Raw data have been uniformly processed to increase comparability and the portal is implemented with visualization tools to browse the data without download.

    • Sarah B. Reiff
    • Andrew J. Schroeder
    • Peter J. Park
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Glunk et al. explore target genes and cellular mechanisms related to a metabolic obesity with normal-weight phenotype, and identify a non-coding variant that affects actin remodelling in subcutaneous adipocytes, which in turn affects the capacity of these cells to accumulate lipids.

    • Viktoria Glunk
    • Samantha Laber
    • Melina Claussnitzer
    Research
    Nature Metabolism
    Volume: 5, P: 861-879

  • Homologs are paired in Drosophila somatic cells from embryogenesis to adulthood. Using a computational approach for haplotype-resolved Hi-C, the authors reveal highly structured homolog pairing in Drosophila embryos during zygotic genome activation and demonstrate its application to mammalian embryos.

    • Jelena Erceg
    • Jumana AlHaj Abed
    • C.-ting Wu
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • This study describes the integrative analysis of 111 reference human epigenomes, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression; the results annotate candidate regulatory elements in diverse tissues and cell types, their candidate regulators, and the set of human traits for which they show genetic variant enrichment, providing a resource for interpreting the molecular basis of human disease.

    • Anshul Kundaje
    • Wouter Meuleman
    • Manolis Kellis
    ResearchOpen Access
    Nature
    Volume: 518, P: 317-330