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Showing 1–3 of 3 results
Advanced filters: Author: Ngee-Soon Lau Clear advanced filters

  • Long-term machine perfusion of human livers outside the body is an emerging field with tremendous potential for the assessment, recovery, and modification of organs prior to transplantation. Here, the authors report the long-term ex situ perfusion of human livers and demonstrate the ability to split and perfuse these organs using a standardised protocol.

    • Ngee-Soon Lau
    • Mark Ly
    • Carlo Pulitano
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Developing clinically predictive model systems for evaluating gene transfer and gene editing technologies has become increasingly important. This study introduces human liver ex situ normothermic perfusion as a model to evaluate gene therapy vectors, paving the way for advanced liver disease treatment.

    • Marti Cabanes-Creus
    • Sophia H. Y. Liao
    • Leszek Lisowski
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Long-term machine perfusion holds great promise in the field of liver transplantation, potentially allowing for extended viability checks as well as treatment of marginal discarded organs. Here, the authors discuss the advances in machine perfusion techniques for liver transplants as well as future potential clinical avenues that it will open up including potential splitting of livers.

    • Ngee-Soon Lau
    • Geoffrey McCaughan
    • Carlo Pulitano
    ReviewsOpen Access
    Nature Communications
    Volume: 15, P: 1-10