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Showing 1–10 of 10 results
Advanced filters: Author: Nghia Millard Clear advanced filters

  • Single-cell transcriptomic and proteomic data from synovial tissue from individuals with rheumatoid arthritis classify patients into groups based on abundance of cell states that can provide insights into pathology and predict individual treatment responses.

    • Fan Zhang
    • Anna Helena Jonsson
    • Soumya Raychaudhuri
    ResearchOpen Access
    Nature
    Volume: 623, P: 616-624

  • The number of single-cell RNA-seq datasets generated is increasing rapidly, making methods that map cell types to well-curated references increasingly important. Here, the authors propose an accurate method for mapping single cells onto a reference atlas in seconds.

    • Joyce B. Kang
    • Aparna Nathan
    • Soumya Raychaudhuri
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21

  • Harmony, for the integration of single-cell transcriptomic data, identifies broad and fine-grained populations, scales to large datasets, and can integrate sequencing- and imaging-based data.

    • Ilya Korsunsky
    • Nghia Millard
    • Soumya Raychaudhuri
    Research
    Nature Methods
    Volume: 16, P: 1289-1296

  • A study finds that a protease called granzyme K can activate the entire complement cascade, explaining how it can drive destructive inflammation in inflammatory diseases such as rheumatoid arthritis.

    • Carlos A. Donado
    • Erin Theisen
    • Michael B. Brenner
    Research
    Nature
    Volume: 641, P: 211-221

  • Fibroblasts play critical roles in tissue homeostasis, but in pathologic states they can drive fibrosis, inflammation, and tissue destruction. Here, Faust et al. find that healthy human synovial fibroblasts under the influence of adjacent adipocytes have altered lipid metabolism driven by cortisol signaling. Both adipocytes and these characteristics are lost in inflammatory arthritis.

    • Heather J. Faust
    • Tan-Yun Cheng
    • Michael B. Brenner
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Insufficient AHR activation has been suggested in SLE, and augmenting AHR activation therapeutically may prevent CXCL13+ TPH/TFH differentiation and the subsequent recruitment of B cells and formation of lymphoid aggregates in inflamed tissues.

    • Calvin Law
    • Vanessa Sue Wacleche
    • Deepak A. Rao
    Research
    Nature
    Volume: 631, P: 857-866

  • The epigenetic changes underlying the heterogeneity of RA disease presentation have been the subject of intense scrutiny. In this study, the authors use multiple single-cell sequencing datasets to define ‘chromatin superstates’ in patients with RA, which associate with distinct transcription factors and disease phenotypes.

    • Kathryn Weinand
    • Saori Sakaue
    • Soumya Raychaudhuri
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-25