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Inferring structural variant cancer cell fraction

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Marek Cmero
Ke Yuan
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-15
Pathogenic variants reveal candidate genes for prostate cancer germline testing for men of African ancestry

African ancestry is a known risk factor for prostate cancer development, but the genetic determinants of this are incompletely understood. Here, the authors identify 172 potentially pathogenic variants which are enriched in an African population.

Kazzem Gheybi
Pamela X. Y. Soh
Vanessa M. Hayes
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Author Correction: Advances in sliding clip renorrhaphy for partial nephrectomy

David Homewood
Tayla Fay
Dinesh Agarwal
Amendments and Corrections05 Jul 2024
Nature Reviews Urology

Volume: 21, P: 761
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer

Primary prostate tumours are known to be genetically heterogeneous and clonal selection has the potential to drive metastasis. Here Hong et al. show that the acquisition of TP53 mutations is linked to clonal expansion and metastatic progression to lethality.

Matthew K.H. Hong
Geoff Macintyre
Christopher M. Hovens
ResearchOpen Access01 Apr 2015
Nature Communications

Volume: 6, P: 1-12
Androgen synthesis in prostate cancer: do all roads lead to Rome?

Treatment with androgen-deprivation therapy can delay the progression of prostate cancer. However, acquired resistance to such approaches is very common. Here the authors describe the role of androgen synthesis pathways, including the specific relevance of each individual pathway, to the development of castration-resistant prostate cancer.

Ryan Stuchbery
Patrick J. McCoy
Niall M. Corcoran
Reviews08 Nov 2016
Nature Reviews Urology

Volume: 14, P: 49-58
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Author Correction: Inferring structural variant cancer cell fraction

Marek Cmero
Ke Yuan
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Circulating endothelial cells as biomarkers of prostate cancer

Prostate cancer has a wide spectrum of biological aggressiveness, but characterization of prostate-cancer aggressiveness at the time of diagnosis can be difficult. Tumor vascularization positively correlates with disease progression and, therefore, markers of angiogenesis could be indicators of clinical outcomes. Circulating endothelial progenitors and circulating endothelial cells play an integral part in neovascularization, and in this Review the authors discuss the potential of these cells as prognostic indicators.

Harry D Georgiou
Benjamin Namdarian
Christopher M Hovens
Reviews01 Aug 2008
Nature Clinical Practice Urology

Volume: 5, P: 445-454
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Advances in sliding clip renorrhaphy for partial nephrectomy

Partial nephrectomy aims to provide both effective oncological management and renal function preservation. Surgical complications pertaining to the defect created during a partial nephrectomy include haemorrhage and urinary leak. We explore advances in techniques for managing the defect created during a partial nephrectomy (renorrhaphy).

David Homewood
Tayla Fay
Dinesh Agarwal
Comments & Opinion25 Jun 2024
Nature Reviews Urology

Volume: 21, P: 703-704
Paraneoplastic syndromes in prostate cancer

Clinical diagnosis of paraneoplastic syndromes not only leads to detection of the underlying malignancy but can also influence treatment. Here, Hong et al. outline the various syndromes associated with prostate cancer, focusing particularly on the identification of putative markers in prostate cancer tissue that might provide a link to the associated syndrome.

Matthew K. Hong
Jennifer Kong
Niall M. Corcoran
Reviews08 Dec 2010
Nature Reviews Urology

Volume: 7, P: 681-692
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Comparing nodal versus bony metastatic spread using tumour phylogenies

Stefano Mangiola
Matthew K. H. Hong
Christopher M. Hovens
ResearchOpen Access22 Sept 2016
Scientific Reports

Volume: 6, P: 1-10
MSH2-deficient prostate tumours have a distinct immune response and clinical outcome compared to MSH2-deficient colorectal or endometrial cancer

Patrick McCoy
Stefano Mangiola
Christopher M. Hovens
Research09 Jun 2021
Prostate Cancer and Prostatic Diseases

Volume: 24, P: 1167-1180
A urinary microRNA signature can predict the presence of bladder urothelial carcinoma in patients undergoing surveillance

Nikhil Sapre
Geoff Macintyre
Christopher M Hovens
ResearchOpen Access26 Jan 2016
British Journal of Cancer

Volume: 114, P: 454-462

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