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Showing 1–2 of 2 results
Advanced filters: Author: Nianxin Guo Clear advanced filters

  • Diels-Alderases (DAs), enzymes catalyzing [4 + 2] cycloaddition reactions, are of high interest, but insights into their evolution are lacking. Here, the authors investigate the evolutionary origins of the intermolecular DAs in the biosynthesis of Moraceae plant-derived Diels-Alder-type secondary metabolites, suggesting they evolved from an ancestor functioning as a flavin adenine dinucleotide-dependent oxidocyclase.

    • Qi Ding
    • Nianxin Guo
    • Xiaoguang Lei
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • The asymmetric total synthesis of alchivemycin A is reported. The synthesis uses a chemoenzymatic approach that comprises de novo skeleton construction and a late-stage enzymatic oxidation cascade.

    • Haoran Dong
    • Nianxin Guo
    • Xiaoguang Lei
    Research
    Nature Synthesis
    Volume: 3, P: 1124-1133