Nature Search

Optogenetic dissection of transcriptional repression in a multicellular organism

Using optogenetics in the fly embryo, this study investigates how a transcriptional repressor drives switch-like, rapidly reversible repression by modulating transcriptional burst frequency, offering insights into gene regulation dynamics in development.

Jiaxi Zhao
Nicholas C. Lammers
Hernan G. Garcia
ResearchOpen Access26 Oct 2024
Nature Communications

Volume: 15, P: 1-11
Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation

The transcriptional regulator YAP controls cellular decisions such as proliferation, differentiation, and pluripotency. Here, the authors show a concentration-dependent and temporal communication code for YAP that enables cells to choose between these programs.

Kirstin Meyer
Nicholas C. Lammers
Orion D. Weiner
ResearchOpen Access30 Oct 2023
Nature Communications

Volume: 14, P: 1-18
Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport

LIS1 is a critical activator of dynein-mediated retrograde transport. Ton et al. reveal that microtubule binding by dynein initiates a cascade of structural changes that trigger LIS1 dissociation from dynein prior to transport, providing insights into dynein activation.

William D. Ton
Yue Wang
Steven M. Markus
Research15 Jun 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1365-1379
Situational factors shape moral judgements in the trolley dilemma in Eastern, Southern and Western countries in a culturally diverse sample

Including participants from 45 countries, Bago et al. find that the situational factors that affect moral reasoning are shared across countries, with diminished observed cultural variation.

Bence Bago
Marton Kovacs
Balazs Aczel
Research14 Apr 2022
Nature Human Behaviour

Volume: 6, P: 880-895
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

Michael Cho and colleagues report a genome-wide association study of risk for chronic obstructive pulmonary disease (COPD) in a large, multi-ancestry cohort. They identify 22 genome-wide significant loci, including 13 not previously associated with COPD and 4 not previously associated with any lung function trait.

Brian D Hobbs
Kim de Jong
Michael H Cho
Research06 Feb 2017
Nature Genetics

Volume: 49, P: 426-432
Publisher Correction: Situational factors shape moral judgements in the trolley dilemma in Eastern, Southern and Western countries in a culturally diverse sample

Bence Bago
Marton Kovacs
Balazs Aczel
Amendments and Corrections06 Jun 2022
Nature Human Behaviour

Volume: 6, P: 897-898
Fingerprinting construction sand-supply networks for traceable sourcing

Natural sand signatures related to the source of sand used in concrete production, are retained during processing and can be identified using conventional petrographic and geochemistry techniques combined with a machine learning image processing tool.

Zachary T. Sickmann
Nicholas C. Lammers
Aurora Torres
ResearchOpen Access02 Nov 2023
Communications Earth & Environment

Volume: 4, P: 1-11
Differential expression and translocation of protein tyrosine phosphatase 1B-related proteins in ME-180 tumor cells expressing apoptotic sensitivity and resistance to tumor necrosis factor: potential interaction with epidermal growth factor receptor

Margot Perez
Brian Haschke
Nicholas J Donato
Research08 Feb 1999
Oncogene

Volume: 18, P: 967-978

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