Nature Search

Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank

Many chronic diseases present with desynchronized sleep-wake cycles, indicative of disrupted biorhythms. Here, the authors propose peripheral thermoregulation as a digital biomarker based on the association between lower temperature rhythms measured from wearable activity trackers with future onset of disease, such as type 2 diabetes, non-alcoholic fatty liver disease, hypertension and pneumonia.

Thomas G. Brooks
Nicholas F. Lahens
Carsten Skarke
ResearchOpen Access24 Aug 2023
Nature Communications

Volume: 14, P: 1-10
MOCCASIN: a method for correcting for known and unknown confounders in RNA splicing analysis

Confounding factors on gene expression analysis can be analyzed by several existing tools. Here the authors develop an algorithm called MOCCASIN to correct the effect of known and unknown confounders on RNA splicing quantification.

Barry Slaff
Caleb M. Radens
Yoseph Barash
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-9
Comparative evaluation of RNA-Seq library preparation methods for strand-specificity and low input

Dimitra Sarantopoulou
Soon Yew Tang
Gregory R. Grant
ResearchOpen Access17 Sept 2019
Scientific Reports

Volume: 9, P: 1-10
A circadian clock regulates efflux by the blood-brain barrier in mice and human cells

The blood-brain barrier is critical for neural function. Here, the authors show that efflux of xenobiotics through the BBB follows a circadian rhythm in mice and human cells.

Shirley L. Zhang
Nicholas F. Lahens
Amita Sehgal
ResearchOpen Access27 Jan 2021
Nature Communications

Volume: 12, P: 1-12
RNA splicing analysis using heterogeneous and large RNA-seq datasets

Here the authors develop MAJIQ v2 to address challenges in detection, quantification, and visualization of RNA splicing variations from large heterogeneous RNA-Seq datasets. They then apply it to analyze 2,335 samples from 13 brain subregions.

Jorge Vaquero-Garcia
Joseph K. Aicher
Yoseph Barash
ResearchOpen Access03 Mar 2023
Nature Communications

Volume: 14, P: 1-20
Diurnal variation of wearable device-based heart rate variability in the Chronic Renal Insufficiency Cohort study

Carsten Skarke
Wei Yang
Panduranga S. Rao
ResearchOpen Access13 Nov 2025
npj Digital Medicine

Volume: 8, P: 1-7
A Pilot Characterization of the Human Chronobiome

Carsten Skarke
Nicholas F. Lahens
Garret A. FitzGerald
ResearchOpen Access07 Dec 2017
Scientific Reports

Volume: 7, P: 1-12
The Nephila clavipes genome highlights the diversity of spider silk genes and their complex expression

Benjamin Voight and colleagues report the annotated genome of the golden orb-weaver spider. They describe 28 spider silk genes (spidroins), characterize their expression in distinct silk gland types and identify non-spidroin genes with expression patterns suggesting potential roles in silk production.

Paul L Babb
Nicholas F Lahens
Benjamin F Voight
ResearchOpen Access01 May 2017
Nature Genetics

Volume: 49, P: 895-903
Challenges and best practices in omics benchmarking

In this Review, the authors summarize and discuss guidelines for omics benchmarking. They highlight common oversights and difficulties, offer guidance for frequently encountered issues and provide a structured form that can be used for comprehensive reporting of benchmarking studies.

Thomas G. Brooks
Nicholas F. Lahens
Gregory R. Grant
Reviews12 Jan 2024
Nature Reviews Genetics

Volume: 25, P: 326-339

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Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank

MOCCASIN: a method for correcting for known and unknown confounders in RNA splicing analysis

Comparative evaluation of RNA-Seq library preparation methods for strand-specificity and low input

A circadian clock regulates efflux by the blood-brain barrier in mice and human cells

RNA splicing analysis using heterogeneous and large RNA-seq datasets

Diurnal variation of wearable device-based heart rate variability in the Chronic Renal Insufficiency Cohort study

A Pilot Characterization of the Human Chronobiome

The Nephila clavipes genome highlights the diversity of spider silk genes and their complex expression

Challenges and best practices in omics benchmarking

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