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Showing 1–5 of 5 results
Advanced filters: Author: Nicholas Franko Clear advanced filters

  • Convergent mutations in hot spots of the spike proteins of currently circulating SARS-CoV-2 Omicron variants increase the binding affinity for the host receptor and promote more efficient fusion with host cell membranes.

    • Amin Addetia
    • Luca Piccoli
    • David Veesler
    ResearchOpen Access
    Nature
    Volume: 621, P: 592-601

  • Combinatorial experimental and bioinformatics methods can be used to analyse function and specificity of CD8 T cells. Here the authors propose a multiomic analysis framework Antigen-TCR Pairing and Multiomic Analysis of T cell (APMAT) to relate TCR specificity to transcriptomic phenotype indicating associations with physicochemical features.

    • Jingyi Xie
    • Daniel G. Chen
    • James R. Heath
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Pseudovirus assays and surface plasmon resonance show that the Omicron receptor-binding domain binds to human ACE2 with increased affinity relative to the ancestral virus, and that most neutralizing antibodies are considerably less potent against Omicron.

    • Elisabetta Cameroni
    • John E. Bowen
    • Davide Corti
    Research
    Nature
    Volume: 602, P: 664-670

  • A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

    • Marnix H Medema
    • Renzo Kottmann
    • Frank Oliver Glöckner
    Comments & OpinionOpen Access
    Nature Chemical Biology
    Volume: 11, P: 625-631