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Nature Chemical Biology (1)

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Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

A screening approach finds VH-domain antibodies that bind the SARS-CoV-2 Spike protein receptor-binding domain at its interface with host ACE2. Bi-paratopic and multivalent binders have high affinity and potency.

Colton J. Bracken
Shion A. Lim
James A. Wells
Research20 Oct 2020
Nature Chemical Biology

Volume: 17, P: 113-121

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Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

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