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Showing 1–16 of 16 results
Advanced filters: Author: Nicholas P. D. Liau Clear advanced filters

  • Here the authors developed ‘Lamina-Inducible Methylation and Hi-C’ (LIMe-Hi-C) to simultaneously measure chromosome conformation, DNA methylation, and nuclear lamina positioning. Application of the method revealed dynamic changes upon PRC2 inhibition and an essential function of H3K27me3 in regulating sub-compartments and lamina association.

    • Allison P. Siegenfeld
    • Shelby A. Roseman
    • Brian B. Liau
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Base editor technology combined with a fluorescent reporter of DNA methyltransferase activity enable in situ mutational scanning of DNMT3A, revealing a requirement of DNA binding by the PWWP histone reader domain for full activity.

    • Nicholas Z. Lue
    • Emma M. Garcia
    • Brian B. Liau
    Research
    Nature Chemical Biology
    Volume: 19, P: 176-186

  • Genomic profiling of tumours can help tailer treatments to the patient, however, it often fails to accurately predict therapeutic outcomes. Here, the authors combine molecular and functional characterisation via BH3 profiling to identify therapeutically targetable vulnerabilities in glioma.

    • Elizabeth G. Fernandez
    • Wilson X. Mai
    • David A. Nathanson
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • IL-15-driven NK cells mediate anti-tumor immunity, but how IL-15 is negatively regulated remains unclear. Huntington and colleagues find that CIS, a member of the suppressor of cytokine signaling family, suppresses the response to IL-15 and, as a result, CIS-deficient mice are more resistant to cancer metastasis.

    • Rebecca B Delconte
    • Tatiana B Kolesnik
    • Nicholas D Huntington
    Research
    Nature Immunology
    Volume: 17, P: 816-824

  • New delivery platforms are needed to allow broader application of biotherapeutics for CNS diseases. Here, the authors show enhanced CNS delivery with a transport vehicle engineered to bind CD98hc, a highly expressed target at the blood-brain barrier.

    • Kylie S. Chew
    • Robert C. Wells
    • Mihalis S. Kariolis
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Cryo-electron microscopy structure, molecular dynamics and biochemical analyses of the SHOC2–PP1C–MRAS complex demonstrate the dependence of the complex formation on RAS–GTP and identify the determinants of RAS isoform preference for SHOC2–PP1C and specificity of the complex for RAF dephosphorylation.

    • Nicholas P. D. Liau
    • Matthew C. Johnson
    • Jawahar Sudhamsu
    ResearchOpen Access
    Nature
    Volume: 609, P: 400-407

  • The inhibitory protein SOCS3 plays a key part in hematopoiesis by regulating signaling induced by specific cytokines. The crystal structure of SOCS3 bound to JAK2 and a fragment of the interleulkin-6 receptor reveals how SOCS3 targets specific receptor–JAK complexes and how it exerts its inhibitory activity by blocking substrate binding.

    • Nadia J Kershaw
    • James M Murphy
    • Jeffrey J Babon
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 469-476

  • Cytokines are key molecules in controlling haematopoiesis that signal via the JAK/STAT pathway. Here the authors present the structures of SOCS1 bound to its JAK1 target as well as in complex with elonginB and elonginC, providing a molecular explanation for the potent JAK- inhibitory activity of SOCS1.

    • Nicholas P. D. Liau
    • Artem Laktyushin
    • Jeffrey J. Babon
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Structural and biochemical characterization of the phosphastase and immune checkpoint PTP1B reveals the molecular basis of PTBP1B/JAK interaction and plasticity of substrate recognition by PTP1B.

    • Rhiannon Morris
    • Narelle Keating
    • Jeffrey J. Babon
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-11