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Showing 1–3 of 3 results
Advanced filters: Author: Nicholas Pervolarakis Clear advanced filters

  • Epithelial subpopulations are present in the human breast but how these differentiate or form is unclear. Here, the authors use single-cell RNA sequencing of primary human breast epithelial cells to define previously undescribed luminal, basal epithelial subpopulations and ZEB1-positive basal cells.

    • Quy H. Nguyen
    • Nicholas Pervolarakis
    • Kai Kessenbrock
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Premalignant stromal cells from women with germline BRCA1 mutations exhibit increased expression of secreted factors regulating epithelial homeostasis in a paracrine fashion. These secreted factors, such as MMP3, promote premalignant epithelial changes including elevated proliferation and altered differentiation of a subpopulation of luminal progenitor cells.

    • Kevin Nee
    • Dennis Ma
    • Kai Kessenbrock
    Research
    Nature Genetics
    Volume: 55, P: 595-606

  • Lawson et al. review recent advances in single-cell technologies and discuss in detail how they can be leveraged to understand tumour heterogeneity and metastasis.

    • Devon A. Lawson
    • Kai Kessenbrock
    • Zena Werb
    Reviews
    Nature Cell Biology
    Volume: 20, P: 1349-1360