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The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration

The success of allogeneic hematopoietic stem cell transplantation for the treatment of haematological cancers is limited by the morbidity and mortality associated with graft-versus-host disease (GVHD). Here the authors show that the microbial metabolite desaminotyrosine contributes to graft-versus-leukemia responses while protecting against GVHD and promoting mTORC1 and STING-dependent intestinal regeneration.

Sascha Göttert
Erik Thiele Orberg
Hendrik Poeck
ResearchOpen Access20 Oct 2025
Nature Communications

Volume: 16, P: 1-26
DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts

Feuerer and colleagues use multiomic analyses to identify DNA methylation, chromatin accessibility and gene expression programs that govern the tissue adaptation of human skin T_reg cells.

Niklas Beumer
Charles D. Imbusch
Markus Feuerer
ResearchOpen Access16 Jul 2025
Nature Immunology

Volume: 26, P: 1315-1328
Donor regulatory T cells rapidly adapt to recipient tissues to control murine acute graft-versus-host disease

Graft-versus-Host disease is a major complication after allogeneic bone marrow transplantation and is ameliorated by adoptively transferred donor regulatory T cells. Here, the authors apply transcriptomic and TCR profiling to assess regulatory T cell organ-specific adaptation in murine bone marrow transplantation models.

David J. Dittmar
Franziska Pielmeier
Michael Rehli
ResearchOpen Access15 Apr 2024
Nature Communications

Volume: 15, P: 1-16
Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury

Julius C. Fischer
Sascha Göttert
Hendrik Poeck
ResearchOpen Access26 Nov 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-16
Oligoclonal CD4⁺CXCR5⁺ T cells with a cytotoxic phenotype appear in tonsils and blood

Most subsets of CD4⁺ T-follicular helper cells occur in blood and tonsils, but location enforces specific gene expression. One subtype reveals a cytotoxic phenotype, is circulating or extrafollicular, oligoclonal and shares TCRs with other clusters.

Chunguang Liang
Silvia Spoerl
Friederike Berberich-Siebelt
ResearchOpen Access18 Jul 2024
Communications Biology

Volume: 7, P: 1-16
The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity

Nicholas J. Carruthers
Clarissa Strieder-Barboza
Robert W. O’Rourke
ResearchOpen Access30 Aug 2021
Scientific Reports

Volume: 11, P: 1-13

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The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration

DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts

Donor regulatory T cells rapidly adapt to recipient tissues to control murine acute graft-versus-host disease

Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury

Oligoclonal CD4+CXCR5+ T cells with a cytotoxic phenotype appear in tonsils and blood

The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity

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Oligoclonal CD4⁺CXCR5⁺ T cells with a cytotoxic phenotype appear in tonsils and blood