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Showing 1–4 of 4 results

Advanced filters: Author: Nicholas Trahearn Clear advanced filters

Hyper-Stain Inspector: A Framework for Robust Registration and Localised Co-Expression Analysis of Multiple Whole-Slide Images of Serial Histology Sections

Nicholas Trahearn
David Epstein
Nasir Rajpoot
ResearchOpen Access17 Jul 2017
Scientific Reports

Volume: 7, P: 1-13
Epigenetically driven and early immune evasion in colorectal cancer evolution

This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

Eszter Lakatos
Vinaya Gunasri
Trevor A. Graham
ResearchOpen Access05 Nov 2025
Nature Genetics

Volume: 57, P: 3039-3049
Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer

Sottoriva and colleagues combine next-generation sequencing and AI-aided histopathology to assess tumor evolvability in patient samples with long-term follow-up and find that it can be a strong predictor of recurrence in high-risk prostate cancer.

Javier Fernandez-Mateos
George D. Cresswell
Andrea Sottoriva
ResearchOpen Access12 Jul 2024
Nature Cancer

Volume: 5, P: 1334-1351
Exploiting evolutionary steering to induce collateral drug sensitivity in cancer

Evolutionary steering uses therapies to control tumour evolution by exploiting trade-offs. Here, using a barcoding approach applied to large cell populations, the authors explore evolutionary steering in lung cancer cells treated with EGFR inhibitors.

Ahmet Acar
Daniel Nichol
Andrea Sottoriva
ResearchOpen Access21 Apr 2020
Nature Communications

Volume: 11, P: 1-14