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Showing 1–4 of 4 results
Advanced filters: Author: Nicholas van Panhuys Clear advanced filters

  • Autoantigen-presenting dendritic cells are shown to interact with both effector and regulatory T cells, and effector-produced IL-2 activates the transcription factor STAT5 in regulatory T cells, which in turn upregulates suppressive molecules and prevents autoimmunity.

    • Zhiduo Liu
    • Michael Y. Gerner
    • Ronald N. Germain
    Research
    Nature
    Volume: 528, P: 225-230

  • It remains difficult to distinguish cognate APC–T cell interactions in human tissue sections. Clark and colleagues have developed an imaging–machine-learning pipeline that uses deep convolutional and tuned neural networks to identify the combination of distance and cell-shape features that can discriminate between bystander human APC–T cell interactions and cognate interactions in situ.

    • Vladimir M. Liarski
    • Adam Sibley
    • Marcus R. Clark
    Research
    Nature Immunology
    Volume: 20, P: 503-513

  • T cell activation upon TCR signaling can lead to development of effector and memory cells. Roychoudhuri and colleagues show that the transcription factor BACH2 promotes memory CD8+ T cell generation by blocking access to genomic regulatory sites recognized by AP-1.

    • Rahul Roychoudhuri
    • David Clever
    • Nicholas P Restifo
    Research
    Nature Immunology
    Volume: 17, P: 851-860

  • Diverse autoimmune and allergic diseases are associated with polymorphisms in a locus encoding the transcription factor BACH2; here, BACH2 is shown to be a broad regulator of immune activation that stabilizes the differentiation of Treg cells by repressing commitment of CD4+ T cells to alternate cell fates.

    • Rahul Roychoudhuri
    • Kiyoshi Hirahara
    • Nicholas P. Restifo
    Research
    Nature
    Volume: 498, P: 506-510