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Showing 1–3 of 3 results
Advanced filters: Author: Nick Niemann Clear advanced filters

  • Lipids shed by pathogenic mycobacteria have been shown to inhibit NPC1, a lysosomal membrane protein deficient in most cases of a rate inherited lysosomal storage disorder Niemann-Pick disease type C (NPC). Here, authors utilise lipid extracts from clinical Mycobacterium tuberculosis strains, and non-tubercular mycobacteria to investigate their ability to inhibit the NPC pathway.

    • Yuzhe Weng
    • Dawn Shepherd
    • Frances M. Platt
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Far from being a static organelle at the end of the endocytic pathway, the lysosome is capable of dynamically fusing with many organelles as well as the plasma membrane. The lysosome provides hydrolytic enzymes for the degradation of macromolecules, has secretory functions and is important for plasma membrane repair.

    • J. Paul Luzio
    • Paul R. Pryor
    • Nicholas A. Bright
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 8, P: 622-632