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Showing 1–3 of 3 results
Advanced filters: Author: Nico Fleck Clear advanced filters

  • Pathology-oriented multiplexing (PathoPlex) represents a framework for widespread access to multiplexed imaging and computational image analysis of clinical specimens at a relatively high throughput and subcellular resolution.

    • Malte Kuehl
    • Yusuke Okabayashi
    • Victor G. Puelles
    ResearchOpen Access
    Nature
    Volume: 644, P: 516-526

  • In this immunological ancillary study of the PREVAC trial, the authors show that approved Ebola virus vaccines induce memory T-cell responses that persist during the five year follow-up after initial vaccination.

    • Aurélie Wiedemann
    • Edouard Lhomme
    • Huanying Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The antiviral drug nirmatrelvir is the active ingredient in Paxlovid, a SARS-CoV-2 Mpro inhibitor developed by Pfizer, however, its synthetic procedure faces limitations for meeting urgent demand. Here, the authors optimize the key synthetic steps and develop a sustainable route to nirmatrelvir in 7 steps and 3 pots with an overall 70% yield.

    • Joseph R. A. Kincaid
    • Juan C. Caravez
    • Bruce H. Lipshutz
    ResearchOpen Access
    Communications Chemistry
    Volume: 5, P: 1-7