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Showing 1–9 of 9 results
Advanced filters: Author: Nico J. Claassens Clear advanced filters

  • In this Review, Claassenset al. discuss recent advances in microbial autotrophic production platforms, in particular the genetic engineering of autotrophic systems in autotrophic microorganisms, the transplantation of partial or complete CO2fixation pathways and autotrophic energy-harvesting systems into heterotrophs, and the large potential of hybrid systems as autotrophic production platforms. They also explore strategies for the design, quantitative analysis and modular experimental implementation of autotrophic cell factories.

    • Nico J. Claassens
    • Diana Z. Sousa
    • John van der Oost
    Reviews
    Nature Reviews Microbiology
    Volume: 14, P: 692-706

  • Low formate dehydrogenase (FDH) activity limits formate assimilation via the synthetic reductive glycine pathway. In this study, the authors introduce a faster FDH in synthetic formatotrophic E. coli, which boosts growth rates and bioproduction titers from formate as sole carbon source.

    • Aidan E. Cowan
    • Mason Hillers
    • Nico J. Claassens
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • A DNA-binding protein, DnaA, regulates the initiation of chromosomal replication in bacteria. Here, Olivi et al. show that the bacterial chromosome sequesters DnaA in a growth rate-dependent manner, suggesting a role for titration in the coordination of DNA replication.

    • Lorenzo Olivi
    • Stephan Köstlbacher
    • Raymond H. J. Staals
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • There are several pathways for CO2 fixation in photoautotrophic and chemoautotrophic microorganisms. Here, the authors provide experimental demonstration for the operation of the reductive glycine pathway in a natural microorganism, Desulfovibrio desulfuricans.

    • Irene Sánchez-Andrea
    • Iame Alves Guedes
    • Alfons J. M. Stams
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Electromicrobial production can replace fossil carbon with CO2 and electricity as feedstocks for chemical production. This work analyses and compares different electromicrobial production approaches, providing a data-driven roadmap for the sustainable and efficient implementation of this technology.

    • Nico J. Claassens
    • Charles A. R. Cotton
    • Arren Bar-Even
    Research
    Nature Catalysis
    Volume: 2, P: 437-447

  • Metabolic engineering of microbes constitutes a promising strategy to make the industrial production of chemicals more sustainable. This Review discusses recent advances of targeted high-throughput genome editing to construct next-generation cell factories for bioproduction.

    • Suzan Yilmaz
    • Akos Nyerges
    • Nico J. Claassens
    Reviews
    Nature Catalysis
    Volume: 5, P: 751-765

  • Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproduction.

    • Enrico Orsi
    • Nico J. Claassens
    • Steffen N. Lindner
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 12, P: 1-5

  • A key feature of living cells is the cell cycle. In this Perspective, the authors explore attempts to recreate this process and what is still required for an integrated synthetic cell cycle.

    • Lorenzo Olivi
    • Mareike Berger
    • John van der Oost
    ReviewsOpen Access
    Nature Communications
    Volume: 12, P: 1-11