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Showing 1–15 of 15 results

Advanced filters: Author: Nico Pfeifer Clear advanced filters

PP-GWAS: Privacy Preserving Multi-Site Genome-wide Association Studies

Genome-wide association studies reveal genetic influences on complex traits, but multi-site analyses risk exposing sensitive data. Here, the authors develop PP-GWAS, a privacy-preserving method that efficiently enables multi-site analysis of quantitative traits while maintaining data security.

Arjhun Swaminathan
Anika Hannemann
Mete Akgün
ResearchOpen Access09 Dec 2025
Nature Communications

Volume: 16, P: 1-17
Impact of pre-adapted HIV transmission

Jonathan Carlson and colleagues report that pre-adaptation of HIV to a recipient's major histocompatibility complex class I alleles impairs immune control of the virus.

Jonathan M Carlson
Victor Y Du
Paul A Goepfert
Research16 May 2016
Nature Medicine

Volume: 22, P: 606-613
Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV

Analysis of monoclonal antibody responses to the Ebola virus vaccine rVSV-ZEBOV in human volunteers.

Stefanie A. Ehrhardt
Matthias Zehner
Florian Klein
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1589-1600
Dynamics and durability of HIV-1 neutralization are determined by viral replication

Human immunodeficiency virus type 1 (HIV-1)-neutralizing responses can persist for several years, even at low antigen levels, suggesting that an HIV-1 vaccine may be able to elicit a durable antibody response.

Philipp Schommers
Dae Sung Kim
Florian Klein
ResearchOpen Access13 Nov 2023
Nature Medicine

Volume: 29, P: 2763-2774
Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Combination therapy with the anti-HIV-1 monoclonal antibodies 3BNC117 and 10-1074 maintains long-term suppression in the absence of antiretroviral therapy in individuals with antibody-sensitive viral reservoirs.

Pilar Mendoza
Henning Gruell
Michel C. Nussenzweig
Research26 Sept 2018
Nature

Volume: 561, P: 479-484
Inherently interpretable position-aware convolutional motif kernel networks for biological sequencing data

Jonas C. Ditz
Bernhard Reuter
Nico Pfeifer
ResearchOpen Access11 Oct 2023
Scientific Reports

Volume: 13, P: 1-11
Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

Florian Klein and colleagues report that treating viremic HIV-1-infected individuals with the broadly neutralizing antibody 10-1074 reduced virus levels in blood, but antibody-resistant virus did emerge.

Marina Caskey
Till Schoofs
Florian Klein
Research16 Jan 2017
Nature Medicine

Volume: 23, P: 185-191
Target leakage and the use of diagnostic variables in diabetes prediction models

Melike Tombaz
Nico Pfeifer
Andreas K. Nüssler
CorrespondenceOpen Access27 Oct 2025
Nutrition & Diabetes

Volume: 15, P: 1-2
The AIMe registry for artificial intelligence in biomedical research

We present the AIMe registry, a community-driven reporting platform for AI in biomedicine. It aims to enhance the accessibility, reproducibility and usability of biomedical AI models, and allows future revisions by the community.

Julian Matschinske
Nicolas Alcaraz
David B. Blumenthal
Comments & Opinion25 Aug 2021
Nature Methods

Volume: 18, P: 1128-1131
Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Combination of two broadly neutralizing antibodies is effective in reducing HIV-1 viremia and in limiting the emergence of resistant viral variants in individuals harboring antibody-sensitive viruses.

Yotam Bar-On
Henning Gruell
Michel C. Nussenzweig
Research26 Sept 2018
Nature Medicine

Volume: 24, P: 1701-1707
HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

A phase IIa clinical trial shows that the administration of the broadly neutralizing antibody 3BNC117 delays viral rebound following the discontinuation of antiretroviral therapy in patients who were chronically infected with HIV-1.

Johannes F. Scheid
Joshua A. Horwitz
Marina Caskey
Research22 Jun 2016
Nature

Volume: 535, P: 556-560
Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury

Svenja Sydor
Paul Manka
Lars P. Bechmann
ResearchOpen Access14 Aug 2017
Scientific Reports

Volume: 7, P: 1-12
Modeling the Amplification of Immunoglobulins through Machine Learning on Sequence-Specific Features

Matthias Döring
Christoph Kreer
Nico Pfeifer
ResearchOpen Access24 Jul 2019
Scientific Reports

Volume: 9, P: 1-11
A study on interoperability between two Personal Health Train infrastructures in leukodystrophy data analysis

Sascha Welten
Marius de Arruda Botelho Herr
Toralf Kirsten
ResearchOpen Access22 Jun 2024
Scientific Data

Volume: 11, P: 1-20
Whither systems medicine?

Rolf Apweiler
Tim Beissbarth
Olaf Wolkenhauer
ReviewsOpen Access02 Mar 2018
Experimental & Molecular Medicine

Volume: 50, P: e453