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Showing 1–2 of 2 results
Advanced filters: Author: Nicol Birsa Clear advanced filters

  • The authors find that TDP-43 loss of function—the pathology defining the neurodegenerative conditions ALS and FTD—induces novel mRNA polyadenylation events, which have different effects, including an increase in RNA stability, leading to higher protein levels.

    • Sam Bryce-Smith
    • Anna-Leigh Brown
    • Pietro Fratta
    ResearchOpen Access
    Nature Neuroscience
    Volume: 28, P: 2190-2200

  • Maria Giovanna Garone et al. use iPSC and mouse models to evaluate a mechanistic link between aberrant axonal phenotypes in ALS and the alteration of a cross-regulatory circuitry involving three RNA binding proteins: FUS, HuD and FMRP. Their results suggest NRN1 as a potential therapeutic target for ALS and provide further insight into the pathogenesis of this critical disorder.

    • Maria Giovanna Garone
    • Nicol Birsa
    • Alessandro Rosa
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-17