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Mechanisms of joint damage in gout: evidence from cellular and imaging studies

Advances in the fields of cell biology and imaging have allowed researchers to dig deeper into the underlying mechanisms of joint damage in patients with tophaceous gout. This Review describes some of the recent advances in our understanding of bone erosion and cartilage damage in this disease.

Fiona M. McQueen
Ashika Chhana
Nicola Dalbeth
Reviews10 Jan 2012
Nature Reviews Rheumatology

Volume: 8, P: 173-181
Screening for hyperuricaemia and gout: a perspective and research agenda

A screening program for hyperuricaemia and gout would aim to identify those individuals with elevated serum urate and thus enable intervention to prevent the onset of gout. However, the data supporting a role for screening in this setting is far from complete. Stamp and Dalbeth outline the important issues around a screening programme for hyperuricaemia and gout, and highlight areas where further research is required before such a programme could be considered.

Lisa Stamp
Nicola Dalbeth
Reviews19 Aug 2014
Nature Reviews Rheumatology

Volume: 10, P: 752-756
A new 'package of care' strategy for effective gout management

Gout is often poorly managed, with low rates of successful long-term urate lowering. A new 'package of care' intervention for treatment of patients with gout now offers ways to improve outcomes. The intervention, involving both a rheumatologist and gout nurse specialist, provides a framework for best practice in gout management.

Nicola Dalbeth
News & Views31 Jul 2012
Nature Reviews Rheumatology

Volume: 8, P: 507-508
Why compare the effectiveness of suboptimal gout management?

Comparative effectiveness research could help inform the choice of agent for urate-lowering therapy, the central component of successful gout management. However, if such studies reflect current clinical practice, are they comparing poor management with inadequate management?

Nicola Dalbeth
Lisa K. Stamp
News & Views07 Jul 2015
Nature Reviews Rheumatology

Volume: 11, P: 506-507
Progress and controversies in treatment

Important advances have been made in gout therapeutics in 2010. In addition to the development of novel biologic agents, progress has been made in the safe prescribing of colchicine. However, colchicine also became the subject of considerable controversy in the USA when one brand of this drug was granted exclusivity.

Nicola Dalbeth
News & Views02 Feb 2011
Nature Reviews Rheumatology

Volume: 7, P: 77-78
Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations

Mohanraj Krishnan
Amanda Phipps-Green
Daniel E. Weeks
Research02 Mar 2023
Journal of Human Genetics

Volume: 68, P: 463-468
A genome-wide association analysis reveals new pathogenic pathways in gout

Genome-wide association analysis of gout and urate identifies 148 new loci, implicating biological pathways and prioritizing candidate genes involved in inflammatory processes.

Tanya J. Major
Riku Takei
Tony R. Merriman
Research15 Oct 2024
Nature Genetics

Volume: 56, P: 2392-2406
Effects of elevated serum urate on cardiometabolic and kidney function markers in a randomised clinical trial of inosine supplementation

Nicola Dalbeth
Borislav Mihov
Anne Horne
ResearchOpen Access28 Jul 2022
Scientific Reports

Volume: 12, P: 1-11
Correction to: Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects

Riku Takei
Murray Cadzow
Wen-Hua Wei
Amendments and Corrections08 Sept 2020
Journal of Human Genetics

Volume: 66, P: 225
Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout

Tanya J. Major
Riku Takei
Tony R. Merriman
Amendments and Corrections05 Nov 2024
Nature Genetics

Volume: 56, P: 2577
Treat-to-target or treat-to-dissolve strategy to improve gout treatment

Medication adherence in gout is low, and discontinuation of urate-lowering therapy puts patients at risk of flares and cardiovascular events. A strategy to regularly monitor serum urate levels and the dissolution of urate deposits (particularly if visualized by patients) might encourage adherence in the long term.

Pascal Richette
Nicola Dalbeth
Comments & Opinion26 Apr 2024
Nature Reviews Rheumatology

Volume: 20, P: 393-394
The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

The common ABCG2 variant Q141K contributes to hyperuricemia and gout risk. Here, using a human interventional study and a new orthologous mouse model, the authors report a tissue specific pathobiology of the Q141K variant, and support a significant role for ABCG2 in urate excretion in both the kidney and intestine.

Kazi Mirajul Hoque
Eryn E. Dixon
Owen M. Woodward
ResearchOpen Access02 Jun 2020
Nature Communications

Volume: 11, P: 1-15
Discordant American College of Physicians and international rheumatology guidelines for gout management: consensus statement of the Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN)

In this Consensus Statement, an expert panel compares and contrasts recommendations for the management of gout produced by rheumatology organizations and the American College of Physicians (ACP), and present the G-CAN position on the ACP guideline.

Nicola Dalbeth
Thomas Bardin
Robert Terkeltaub
ReviewsOpen Access10 Aug 2017
Nature Reviews Rheumatology

Volume: 13, P: 561-568
Prevention and treatment of gout

In 2018, advances in the treatment of gout flares came in the form of a new nurse-led management approach to serum urate lowering and evidence that allopurinol might have a better cardiovascular safety profile than febuxostat. However, are IL-1β blockers such as canakinumab the future of care for patients with gout?

Lisa K Stamp
Nicola Dalbeth
News & Views13 Dec 2018
Nature Reviews Rheumatology

Volume: 15, P: 68-70
Gout

Gout is a chronic form of arthritis caused by an inflammatory response to deposited monosodium urate crystals. This Primer discusses the epidemiology and pathogenesis of gout and evolving approaches for management of the disease.

Nicola Dalbeth
Hyon K. Choi
Lisa K. Stamp
Reviews26 Sept 2019
Nature Reviews Disease Primers

Volume: 5, P: 1-17
Hyperuricaemia and gout in the Pacific

In this Review, the authors provide an overview of gout and hyperuricaemia in Indigenous peoples of the Pacific region, including discussion of genetic, clinical and cultural aspects and how to address the inequitable health outcomes and suboptimal gout management in these populations.

Baptiste Gérard
Megan Leask
Tristan Pascart
Reviews11 Mar 2025
Nature Reviews Rheumatology

Volume: 21, P: 197-210
The clinical benefits of sodium–glucose cotransporter type 2 inhibitors in people with gout

Gout is associated with various cardiometabolic–renal comorbidities that increase the risk of mortality. Sodium–glucose cotransporter type 2 (SGLT2) inhibitors show promise in both addressing the symptoms of gout and managing relevant comorbidities to help prevent premature mortality.

Chio Yokose
Natalie McCormick
Hyon K. Choi
Reviews12 Mar 2024
Nature Reviews Rheumatology

Volume: 20, P: 216-231
The Māori and Pacific specific CREBRF variant and adult height

Louise K. Metcalfe
Mohanraj Krishnan
Rinki Murphy
Research22 Sept 2019
International Journal of Obesity

Volume: 44, P: 748-752
Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects

Riku Takei
Murray Cadzow
Wen-Hua Wei
Research10 Aug 2020
Journal of Human Genetics

Volume: 66, P: 161-169
Critical appraisal of serum urate targets in the management of gout

Gout can be effectively treated with long-term urate-lowering therapy. Current guidelines advocate the use of a treat-to-target serum urate strategy, with a target serum urate concentration of <5 mg/dl (<0.30 mmol/l) or <6 mg/dl (<0.36 mmol/l), but specific targets are under debate. In this Review, the authors consider the rationale and evidence for the recommendations.

Lisa K. Stamp
Nicola Dalbeth
Reviews16 Aug 2022
Nature Reviews Rheumatology

Volume: 18, P: 603-609
When underlying biology threatens the randomization principle — initial gout flares of urate-lowering therapy

The paradoxical increase in gout flare risk upon initiation of urate-lowering therapy presents challenges for the measurement and analysis of gout flares in clinical trials of urate-lowering therapy. In this Perspective, the authors highlight these issues and discuss potential solutions.

Hyon K. Choi
Yuqing Zhang
Nicola Dalbeth
Reviews25 Jul 2022
Nature Reviews Rheumatology

Volume: 18, P: 543-549
Mouse models for human hyperuricaemia: a critical review

Hyperuricaemia is a risk factor for gout, and mouse models of this condition can help dissect the underlying regulatory mechanisms. However, these models come with both advantages and disadvantages, and interpreting and comparing data from these models can be challenging.

Jie Lu
Nicola Dalbeth
Wen-Hua Wei
Reviews22 May 2019
Nature Reviews Rheumatology

Volume: 15, P: 413-426
An update on the genetics of hyperuricaemia and gout

In this Review, the authors summarize the results of genetics studies that confirm the importance of modulating urate levels in gout pathophysiology, and discuss how these discoveries could be applied to the treatment of hyperuricaemia and gout.

Tanya J. Major
Nicola Dalbeth
Tony R. Merriman
Reviews08 May 2018
Nature Reviews Rheumatology

Volume: 14, P: 341-353
Raman spectroscopy reveals age- and sex-related differences in cortical bone from people with osteoarthritis

Michel K. Nieuwoudt
Rayomand Shahlori
M. Cather Simpson
ResearchOpen Access10 Nov 2020
Scientific Reports

Volume: 10, P: 1-14
Re: “Widespread prevalence of a CREBRF variant among Māori and Pacific children is associated with weight and height in early childhood”

Tanya J Major
Mohanraj Krishnan
Tony R Merriman
Correspondence06 Mar 2018
International Journal of Obesity

Volume: 42, P: 1389-1391

Search

Mechanisms of joint damage in gout: evidence from cellular and imaging studies

Screening for hyperuricaemia and gout: a perspective and research agenda

A new 'package of care' strategy for effective gout management

Why compare the effectiveness of suboptimal gout management?

Progress and controversies in treatment

Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations

A genome-wide association analysis reveals new pathogenic pathways in gout

Effects of elevated serum urate on cardiometabolic and kidney function markers in a randomised clinical trial of inosine supplementation

Correction to: Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects

Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout

Treat-to-target or treat-to-dissolve strategy to improve gout treatment

The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

Discordant American College of Physicians and international rheumatology guidelines for gout management: consensus statement of the Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN)

Prevention and treatment of gout

Gout

Hyperuricaemia and gout in the Pacific

The clinical benefits of sodium–glucose cotransporter type 2 inhibitors in people with gout

The Māori and Pacific specific CREBRF variant and adult height

Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects

Critical appraisal of serum urate targets in the management of gout

When underlying biology threatens the randomization principle — initial gout flares of urate-lowering therapy

Mouse models for human hyperuricaemia: a critical review

An update on the genetics of hyperuricaemia and gout

Raman spectroscopy reveals age- and sex-related differences in cortical bone from people with osteoarthritis

Re: “Widespread prevalence of a CREBRF variant among Māori and Pacific children is associated with weight and height in early childhood”

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