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Showing 1–2 of 2 results
Advanced filters: Author: Nicolaj S. Hackert Clear advanced filters

  • Difficulties can be encountered when translating research between cells from animals and humans because of gene expression differences. Here the authors perform an integrative transcriptomic analysis from human and mouse neutrophils and identify a core inflammation program shared across inflamed contexts.

    • Nicolaj S. Hackert
    • Felix A. Radtke
    • Ricardo Grieshaber-Bouyer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • Fine-mapping has previously implicated the non-coding single nucleotide polymorphism rs117701653 as a risk variant for rheumatoid arthritis and type 1 diabetes, however its function remained unclear. Here the authors show that this variant decreases binding of the inhibitory factor SMCHD1 to enhance expression of ICOS, promoting development of potentially pathogenic T peripheral helper cells.

    • Taehyeung Kim
    • Marta Martínez-Bonet
    • Peter A. Nigrovic
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14