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Showing 1–7 of 7 results
Advanced filters: Author: Nicolas Danchin Clear advanced filters

  • In a large, new, observational study, β-blocker treatment did not improve clinical outcomes in patients with coronary artery disease (CAD), including those with previous myocardial infarction, and was associated with more events in individuals with risk factors only. The role of β-blockers for secondary prevention in these patients should be reconsidered.

    • Nicolas Danchin
    • Stéphane Laurent
    News & Views
    Nature Reviews Cardiology
    Volume: 10, P: 11-12

  • Immune cells contribute to adverse remodeling following myocardial infarction. Here the authors show in mice and pigs that CD8+ lymphocytes release Granzyme B in the infarcted heart leading to cardiomyocyte death, enhanced inflammation and deterioration of cardiac function.

    • Icia Santos-Zas
    • Jeremie Lemarié
    • Hafid Ait-Oufella
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • After myocardial infarction, inflammatory cells are rapidly recruited to the heart and strongly affect the course of recovery. Ziad Mallat and his colleagues uncover a pathogenic role for B cells after myocardial infarction, showing that infarction triggers B cell secretion of the chemokine Ccl7, which mobilizes monocytes from the bone marrow, increases their recruitment to the heart and impairs heart function.

    • Yasmine Zouggari
    • Hafid Ait-Oufella
    • Ziad Mallat
    Research
    Nature Medicine
    Volume: 19, P: 1273-1280

  • A range of drugs is available for symptomatic angina, but the optimal choice or combination of therapies is often uncertain, and contemporary guidelines do not necessarily provide definite recommendations. In this Consensus Statement, Ferrari and colleagues propose an individualized approach to angina treatment, which takes into consideration the patient, their comorbidities, and the underlying mechanism of disease.

    • Roberto Ferrari
    • Paolo G. Camici
    • José L. Lopez-Sendon
    ReviewsOpen Access
    Nature Reviews Cardiology
    Volume: 15, P: 120-132