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Cadherin-dependent filopodia control preimplantation embryo compaction

It has been unclear how round cells elongate during mouse embryo compaction. Plachta and colleagues use live imaging to demonstrate that E-cadherin-dependent filopodia extend to neighbouring cells to drive elongation and compaction.

Juan Carlos Fierro-González
Melanie D. White
Nicolas Plachta
Research24 Nov 2013
Nature Cell Biology

Volume: 15, P: 1424-1433
The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization

Contractile forces are key to sorting the embryonic inner cell mass from the extraembryonic trophectoderm. Here they show that Lamin-A links changes in mechanical forces to cell fate specification, enabling Yap-Cdx2 signaling in outer, but not inner cells.

Robin M. Skory
Adam A. Moverley
Nicolas Plachta
ResearchOpen Access29 May 2023
Nature Communications

Volume: 14, P: 1-14
Erratum: Oct4 kinetics predict cell lineage patterning in the early mammalian embryo

Nicolas Plachta
Tobias Bollenbach
Periklis Pantazis
Amendments and Corrections01 Mar 2011
Nature Cell Biology

Volume: 13, P: 337
A monoastral mitotic spindle determines lineage fate and position in the mouse embryo

Pomp et al. show that specification of inner cell mass versus trophectoderm depends on a monoastral spindle that drives asymmetric cell division patterns, arguing against a stochastic inner–outer lineage segregation in the mouse embryo.

Oz Pomp
Hui Yi Grace Lim
Nicolas Plachta
Research31 Jan 2022
Nature Cell Biology

Volume: 24, P: 155-167
Pretreatment with IL-15 and IL-18 rescues natural killer cells from granzyme B-mediated apoptosis after cryopreservation

Natural killer (NK) cells are assessed for various therapies, but sub-optimal cryopreservation dampens their clinical feasibility. Here the authors show that pretreating human NK cells with IL-15/IL-18 prior to cryopreservation improves NK cell post-thaw viability and functions, potentially via anti-apoptosis gene induction and granzyme B degranulation.

Abdulla Berjis
Deeksha Muthumani
Neil C. Sheppard
ResearchOpen Access10 May 2024
Nature Communications

Volume: 15, P: 1-13
Keratins are asymmetrically inherited fate determinants in the mammalian embryo

Keratins are determinants of cell fate during mammalian embryogenesis, and are distributed asymmetrically between daughter cells during cell division.

Hui Yi Grace Lim
Yanina D. Alvarez
Nicolas Plachta
Research26 Aug 2020
Nature

Volume: 585, P: 404-409
Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells

Nicolas Plachta
Christine Annaheim
Yves-Alain Barde
Research07 May 2007
Nature Neuroscience

Volume: 10, P: 712-719
Probing transcription factor diffusion dynamics in the living mammalian embryo with photoactivatable fluorescence correlation spectroscopy

Transcription factor diffusion along DNA regulates many fundamental cellular and developmental processes. Kaur et al. combine photoactivation and fluorescence correlation spectroscopy to investigate transcription factor diffusion in mouse embryos and show that diffusion kinetics change during cell differentiation.

Gurpreet Kaur
Mauro W. Costa
Nicolas Plachta
Research27 Mar 2013
Nature Communications

Volume: 4, P: 1-13
Oct4 kinetics predict cell lineage patterning in the early mammalian embryo

Very little is known about the role of transcription factors DNA-binding dynamics in defining development and pluriotency. Cells in the early mouse embryo display two classes of Oct4 kinetics that define two subpopulations of cells with distinct lineage potential.

Nicolas Plachta
Tobias Bollenbach
Periklis Pantazis
Research23 Jan 2011
Nature Cell Biology

Volume: 13, P: 117-123
Cytoskeletal control of early mammalian development

The cytoskeleton has been extensively implicated in regulating cell function and behaviour during development. This Review analyses the functional organization of cytoskeletal components in the early mouse embryo, and discusses key roles of the cytoskeleton during early mammalian embryogenesis, including regulation of cell fate specification and morphogenesis of the blastocyst.

Hui Yi Grace Lim
Nicolas Plachta
Reviews29 Apr 2021
Nature Reviews Molecular Cell Biology

Volume: 22, P: 548-562
Quantifying transcription factor–DNA binding in single cells in vivo with photoactivatable fluorescence correlation spectroscopy

To quantify transcription factor (TF)–DNA binding dynamics in vivo, this protocol describes how to perform photoactivatable fluorescence correlation spectroscopy in live mouse embryos via selective photoactivation of a subpopulation of TF molecules.

Ziqing Winston Zhao
Melanie D White
Nicolas Plachta
Protocols29 Jun 2017
Nature Protocols

Volume: 12, P: 1458-1471

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Cadherin-dependent filopodia control preimplantation embryo compaction

The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization

Erratum: Oct4 kinetics predict cell lineage patterning in the early mammalian embryo

A monoastral mitotic spindle determines lineage fate and position in the mouse embryo

Pretreatment with IL-15 and IL-18 rescues natural killer cells from granzyme B-mediated apoptosis after cryopreservation

Keratins are asymmetrically inherited fate determinants in the mammalian embryo

Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells

Probing transcription factor diffusion dynamics in the living mammalian embryo with photoactivatable fluorescence correlation spectroscopy

Oct4 kinetics predict cell lineage patterning in the early mammalian embryo

Cytoskeletal control of early mammalian development

Quantifying transcription factor–DNA binding in single cells in vivo with photoactivatable fluorescence correlation spectroscopy

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