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Showing 1–4 of 4 results
Advanced filters: Author: Nicolas Tarbouriech Clear advanced filters

  • The human colony-stimulating factor (hCSF-1) cytokine is essential for innate and adaptive immune responses. The Epstein-Barr virus protein BARF1 binds to hCSF-1, preventing interferon-α secretion. Structural and functional data reveal a new mechanism for the antagonism of human but not mouse CSF-1 signaling by BARF1.

    • Jonathan Elegheert
    • Nathalie Bracke
    • Savvas N Savvides
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 938-947

  • Replication of Nipah virus, which causes human encephalitis, requires delivery of viral nucleoprotein N to the viral genome by phosphoprotein chaperone, P. The crystal structure of the N0–P core complex now reveals how the chaperone prevents premature N assembly on RNA and identifies a potential target for antiviral drugs.

    • Filip Yabukarski
    • Philip Lawrence
    • Marc Jamin
    Research
    Nature Structural & Molecular Biology
    Volume: 21, P: 754-759

  • The catalytic subunit E9 of the vaccinia virus DNA polymerase forms a functional polymerase holoenzyme by interacting with the heterodimeric processivity factor A20/D4. Here the authors present the structure of full-length E9 and show that an insertion within its palm domain binds A20, in a mode different from other family B polymerases.

    • Nicolas Tarbouriech
    • Corinne Ducournau
    • Frédéric Iseni
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12