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Showing 1–6 of 6 results
Advanced filters: Author: Nicolas van Baren Clear advanced filters

  • Inhibiting TGF-β1 to increase immune responses against tumors bears the risk of tumor-promoting toxicity. Here the authors show that selectively blocking TGF-β1 produced by immunosuppressive cells is feasible with anti-GARP:TGF-β1 antibodies and improves the efficacy of PD-1 blockade immunotherapy.

    • Grégoire de Streel
    • Charlotte Bertrand
    • Sophie Lucas
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Cancer immunotherapy is ineffective in a subset of patients. Here the authors show that, in a mouse model of melanoma, resistance to immune checkpoint inhibitors relies on loss of tumor-specific T cells through FasL-mediated apoptosis triggered by polymorphonuclear-myeloid-derived suppressor cells.

    • Jingjing Zhu
    • Céline G. Powis de Tenbossche
    • Benoit J. Van den Eynde
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • Obesity is associated with altered N-acylethanolamine levels (NAE). Here the authors show that deletion of the gene encoding N-acylphosphatidylethanolamine phospholipase D, a key enzyme for NAE synthesis, in intestinal cells of mice leads to the development of obesity and hepatic steatosis via a mechanism involving the gut-brain axis.

    • Amandine Everard
    • Hubert Plovier
    • Patrice D. Cani
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Uveal melanoma has a propensity to metastasise. Here, the authors report the whole genome sequence of 103 uveal melanomas and find that the tumour mutational burden is variable and that two subsets of tumours are characterised by MBD4 mutations and a UV exposure signature.

    • Peter A. Johansson
    • Kelly Brooks
    • Nicholas K. Hayward
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • As part of the modENCODE initiative, which aims to characterize functional DNA elements in D. melanogaster and C. elegans, this study uses RNA-Seq, tiling microarrays and cDNA sequencing to explore the transcriptome in 30 distinct developmental stages of the fruitfly. Among the results are scores of new genes, coding and non-coding transcripts, as well as splicing and editing events.

    • Brenton R. Graveley
    • Angela N. Brooks
    • Susan E. Celniker
    Research
    Nature
    Volume: 471, P: 473-479