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Showing 1–12 of 12 results
Advanced filters: Author: Nicole Baumgarth Clear advanced filters

  • In this Review, Nicole Baumgarth describes the development and functions of B-1 cells. These innate-like B cells serve as the major source of natural antibody in mice, and can have important roles in defence against mucosal pathogens and in maintaining tissue homeostasis.

    • Nicole Baumgarth
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 34-46

  • Il-10-expressing B cells play a pivotal role in immune homeostasis, but little is known about the factors and pathways that affect the development of this heterologous population of regulatory B cells. Here authors show in a mouse model that in embryonic life, soluble IgM restrains the expansion of Il-10-positive B cells, via utilizing FcµR and other putative receptors.

    • Shannon Eileen McGettigan
    • Lazaro Emilio Aira
    • Gudrun F. Debes
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • FcμR serves as a receptor for soluble IgM. Baumgarth and colleagues show that intracellular FcμR constrains the surface expression of IgM. Lack of FcμR alters B cell populations and enhances autoantibody production. FcμR thereby serves as a critical regulator of B cell homeostasis.

    • Trang T T Nguyen
    • Kathrin Kläsener
    • Nicole Baumgarth
    Research
    Nature Immunology
    Volume: 18, P: 321-333

  • The antimicrobial peptide LL37 is essential for normal immune responses to infection or tissue injury. But in the autoimmune skin disorder psoriasis, LL37 propagates disease by forming complexes with host DNA.

    • Nicole Baumgarth
    • Charles L. Bevins
    News & Views
    Nature
    Volume: 449, P: 551-553

  • Compared to germinal centres, extrafollicular plasmablast responses are thought to produce lower affinity antibodies, offering little protection from infection. Here authors show in an influenza infection and immunization mouse model that extrafollicular responses could yield protective antibodies, and that their development depends on signals provided via Toll-like receptor stimulation.

    • Jonathan H. Lam
    • Nicole Baumgarth
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Tissue-resident B-1 cells express CD11b, unlike their lymphoid organ-residing counterparts. Here the authors show that influenza-induced type I interferons activate CD11b on B-1 cells, facilitating entry to mediastinal lymph nodes, where they provide the first line of antibody-mediated host defense.

    • Elizabeth E. Waffarn
    • Christine J. Hastey
    • Nicole Baumgarth
    Research
    Nature Communications
    Volume: 6, P: 1-11