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Showing 1–6 of 6 results
Advanced filters: Author: Nicole C Kaneider Clear advanced filters

  • Glutarate rewires cell metabolism through conjugation to proteins or fatty acids, but how glutarylation is regulated is unclear. ABHD11 was identified as a lipoyl-deglutarylase to maintain the TCA cycle and mitochondrial metabolism.

    • Guinevere L. Grice
    • Eleanor Minogue
    • James A. Nathan
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 21, P: 1915-1926

  • Variants of the human gene C13orf31 (LACC1) are associated with various disease risks. Kaser and colleagues identify a role for the protein encoded (called ‘FAMIN’) in regulating macrophage fatty-acid oxidation and lipogenesis.

    • M Zaeem Cader
    • Katharina Boroviak
    • Arthur Kaser
    Research
    Nature Immunology
    Volume: 17, P: 1046-1056

  • This is an Issue edsumm for 934. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence shows that sea surface temperatures near the North Pole increased from roughly 18 degrees Celsius to over 23 degrees Celsius — such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming.

    • Nicole C Kaneider
    • Andrew J Leger
    • Athan Kuliopulos
    Research
    Nature Immunology
    Volume: 8, P: 1303-1312

  • A form of programmed cell death, necroptosis, in intestinal epithelial cells initiates mucosal inflammation. A study now finds that prostanoid EP4 receptor signalling interferes with RIPK1–RIPK3-dependent MLKL activation, thereby inhibiting necroptosis and accelerating resolution of inflammation.

    • Nicole C. Kaneider
    • Arthur Kaser
    News & Views
    Nature Cell Biology
    Volume: 23, P: 680-681

  • GPR35 controls the transmembrane ion gradient by regulating Na/K-ATPase function with knock-on effects on osmosis, cellular stress and glutamine uptake.

    • Joshua E. Elias
    • Mekdes Debela
    • Nicole C. Kaneider
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-13