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Showing 1–4 of 4 results
Advanced filters: Author: Nicole C. Ammerman Clear advanced filters

  • The cytochrome bc1 oxidase of Mycobacterium tuberculosis is a potential target in the fight against tuberculosis. Here, the authors evaluate the potential of cytochrome bc1 inhibitors as partner drugs in tuberculosis treatment regimens.

    • Clara Aguilar-Pérez
    • Anne J. Lenaerts
    • Dirk A. Lamprecht
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9

  • New classes of antitubercular drugs are in constant demand as drug-resistant strains of Mycobacterium tuberculosis become more prevalent. Here, the authors characterize a class of drugs that are active against various M. tuberculosisstrains, including those resistant to currently used antituberculars.

    • Shichun Lun
    • Haidan Guo
    • William R. Bishai
    Research
    Nature Communications
    Volume: 4, P: 1-8

  • The treatment ofMycobacterium tuberculosis with drugs such as isoniazid often results in drug resistance, but the mechanisms leading to the resistance are not fully known. In this study, an M. tuberculosisstrain lacking the sigma factor I is shown to be resistant to isoniazid.

    • Jong-Hee Lee
    • Nicole C. Ammerman
    • William R. Bishai
    Research
    Nature Communications
    Volume: 3, P: 1-8

  • Carbapenem β-lactam antibiotics target non-classical transpeptidases, the L,D-transpeptidases, which act in an alternative Mycobacterium tuberculosis peptidoglycan synthesis pathway, informing the design of evolved carbapenems with improved antibacterial activity.

    • Pankaj Kumar
    • Amit Kaushik
    • Gyanu Lamichhane
    Research
    Nature Chemical Biology
    Volume: 13, P: 54-61