Nature Search

Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes

Mitchell Kronenberg
Joan Goverman
Leroy Hood
Research21 Feb 1985
Nature

Volume: 313, P: 647-653
Human metabolic individuality in biomedical and pharmaceutical research

Karsten Suhre
So-Youn Shin
Christian Gieger
Research31 Aug 2011
Nature

Volume: 477, P: 54-60
Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes

Bioorthogonal diversification of peptides is generally dependent on impractical prefunctionalization methods. Here, the authors develop a manganese(I)-catalyzed C–H fluorescent labeling with BODIPY probes, which enables the development of activatable fluorophores to image cell function.

Nikolaos Kaplaneris
Jongwoo Son
Lutz Ackermann
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-9
miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110

Loss-of-function studies of the miR-34/449 microRNA family in mouse and Xenopus reveal their evolutionarily conserved role in ciliogenesis by repressing expression of the centriolar protein Cp110.

Rui Song
Peter Walentek
Lin He
Research04 Jun 2014
Nature

Volume: 510, P: 115-120
Chemoselective dual functionalization of proteins via 1,6-addition of thiols to trifunctional N-alkylpyridinium

Chemoselective dual functionalization of proteins is an invaluable tool to introduce two distinct payloads to proteins. Here, the authors present N-alkylpyridinium reagents as soft electrophiles for chemoselective dual modification of cysteine residues in peptides or proteins via a 1,6-addition reaction.

Lujuan Xu
Maria J. S. A. Silva
Tanja Weil
ResearchOpen Access06 Jun 2025
Nature Communications

Volume: 16, P: 1-14
Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment

Spatial molecular imaging analysis of human pancreatic adenocarcinomas describes multicellular neighborhoods in the tumor microenvironment. Ligand–receptor analysis using optimal transport-based SCOTIA identifies interleukin-6 as a mediator of chemoresistance.

Carina Shiau
Jingyi Cao
William L. Hwang
Research03 Sept 2024
Nature Genetics

Volume: 56, P: 2466-2478
A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis

Programmed cell death or apoptosis is an essential biological process that is impaired in some diseases and can be used to assess the effectiveness of drugs. Here the authors design Apo-15 as a fluorogenic peptide for the detection and real-time imaging of apoptotic cells.

Nicole D. Barth
Ramon Subiros-Funosas
Marc Vendrell
ResearchOpen Access12 Aug 2020
Nature Communications

Volume: 11, P: 1-14
A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

Granzyme B is found in activated T cells and can be used as a marker of T cell activation. Here, the authors generate a fluorescent probe that can detect Granzyme B levels in tumours, and has the potential to be used as a biomarker of response to immunotherapy.

Jamie I. Scott
Lorena Mendive-Tapia
Marc Vendrell
ResearchOpen Access02 May 2022
Nature Communications

Volume: 13, P: 1-11
Hormonal contraceptive intake during adolescence and cortical brain measures in the ABCD Study

Carina Heller
Elvisha Dhamala
Nicole Petersen
ResearchOpen Access22 Sept 2025
npj Women's Health

Volume: 3, P: 1-9
Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins

An international blind study confirms that smFRET measurements on dynamic proteins are highly reproducible across instruments, analysis procedures and timescales, further highlighting the promise of smFRET for dynamic structural biology.

Ganesh Agam
Christian Gebhardt
Thorben Cordes
ResearchOpen Access27 Mar 2023
Nature Methods

Volume: 20, P: 523-535
A benzodiazepine activator locks K_v7.1 channels open by electro-mechanical uncoupling

The binding site and mechanism of action for a benzodiazepine-derivative agonist on K_v7.1 channels is determined for drug development to treat long QT syndrome.

Julian A. Schreiber
Melina Möller
Guiscard Seebohm
ResearchOpen Access01 Apr 2022
Communications Biology

Volume: 5, P: 1-13
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity

Nrf1-mediated proteosome activity in brown fat is required for the normal thermogenic behavior of this tissue in mice.

Alexander Bartelt
Scott B Widenmaier
Gökhan S Hotamisligil
Research05 Feb 2018
Nature Medicine

Volume: 24, P: 292-303
The ENIGMA-Neuroendocrinology working group to bridge gaps in female mental health research

We launched the ENIGMA-Neuroendocrinology working group with the aim to address knowledge gaps about the role of sex hormones in the brain, which lead to prevalent sex- and gender-based health disparities in biomedical research. We approach this by adopting a lifespan perspective to explore the interplay of hormonal dynamics and mental health in the brain.

Carina Heller
Claudia Barth
Nicole Petersen
Comments & Opinion27 Mar 2024
Nature Mental Health

Volume: 2, P: 348-350
Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study

A multi-laboratory study finds that single-molecule FRET is a reproducible and reliable approach for determining accurate distances in dye-labeled DNA duplexes.

Björn Hellenkamp
Sonja Schmid
Thorsten Hugel
ResearchOpen Access31 Aug 2018
Nature Methods

Volume: 15, P: 669-676
Publisher Correction: Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study

Björn Hellenkamp
Sonja Schmid
Thorsten Hugel
Amendments and Corrections16 Oct 2018
Nature Methods

Volume: 15, P: 984
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

Sébastien Jacquemont
Alexandre Reymond
Philippe Froguel
Research31 Aug 2011
Nature

Volume: 478, P: 97-102
An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

Sacha Ferdinandusse
Kirsty McWalter
Frédéric M. Vaz
ResearchOpen Access26 Nov 2020
Genetics in Medicine

Volume: 23, P: 740-750
Development of the McLean Hospital MENTOR Program to enhance mental health career pathways

Courtney Beard
Michaela B. Swee
Kerry Ressler
Reviews30 Apr 2025
Neuropsychopharmacology

Volume: 50, P: 1197-1199
Generic acquisition protocol for quantitative MRI of the spinal cord

A protocol for quantitative MRI of the spinal cord using 3T MRI systems from the three main manufacturers: GE, Philips and Siemens. The authors offer guidance for assessing macrostructural and microstructural integrity using various imaging approaches.

Julien Cohen-Adad
Eva Alonso-Ortiz
Junqian Xu
Protocols16 Aug 2021
Nature Protocols

Volume: 16, P: 4611-4632
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Julien Cohen-Adad
Eva Alonso-Ortiz
Junqian Xu
ResearchOpen Access16 Aug 2021
Scientific Data

Volume: 8, P: 1-17
Correction to: An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

Sacha Ferdinandusse
Kirsty McWalter
Frédéric M. Vaz
Amendments and CorrectionsOpen Access19 Oct 2021
Genetics in Medicine

Volume: 23, P: 2467
Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Julien Cohen-Adad
Eva Alonso-Ortiz
Junqian Xu
Amendments and CorrectionsOpen Access23 Sept 2021
Scientific Data

Volume: 8, P: 1-2
Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Julien Cohen-Adad
Eva Alonso-Ortiz
Junqian Xu
Amendments and CorrectionsOpen Access10 Sept 2021
Scientific Data

Volume: 8, P: 1
A multifaceted educational intervention improved anti-infectious measures but had no effect on mortality in patients with severe sepsis

Daniel Schwarzkopf
Claudia Tanja Matthaeus-Kraemer
Gabriele Wöbker
ResearchOpen Access10 Mar 2022
Scientific Reports

Volume: 12, P: 1-13

Search

Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes

Human metabolic individuality in biomedical and pharmaceutical research

Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes

miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110

Chemoselective dual functionalization of proteins via 1,6-addition of thiols to trifunctional N-alkylpyridinium

Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment

A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis

A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

Hormonal contraceptive intake during adolescence and cortical brain measures in the ABCD Study

Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins

A benzodiazepine activator locks K_v7.1 channels open by electro-mechanical uncoupling

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity

The ENIGMA-Neuroendocrinology working group to bridge gaps in female mental health research

Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study

Publisher Correction: Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

Development of the McLean Hospital MENTOR Program to enhance mental health career pathways

Generic acquisition protocol for quantitative MRI of the spinal cord

Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Correction to: An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

A multifaceted educational intervention improved anti-infectious measures but had no effect on mortality in patients with severe sepsis

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