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Retinal phenotype of APOB100 transgenic mice on a Western diet with human-like hyperlipidemia and cholesterol crystals in the retina and choroid

APOB100 mice on a Western diet develop human-like hyperlipidemia, retinal cholesterol buildup, choroidal cholesterol crystals and impaired retinal function, supporting their use for studying lipid contributions to age-related macular degeneration.

Nicole El-Darzi
Tim F. Dorweiler
Irina A. Pikuleva
ResearchOpen Access09 Feb 2026
Lab Animal

P: 1-12

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Retinal phenotype of APOB100 transgenic mice on a Western diet with human-like hyperlipidemia and cholesterol crystals in the retina and choroid

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