Residues within the catalytic site of enzymes are important for activity, but whether more distant residues are also sensitive to mutation is unclear. Here, Leferink et al.show that mutation of residues in copper nitrate reductase that are 12Å away from the active site perturb enzyme function.
- Nicole G. H. Leferink
- Svetlana V. Antonyuk
- S. Samar Hasnain
