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Showing 1–6 of 6 results
Advanced filters: Author: Nicole Holton Clear advanced filters

  • The DNA helicase ASCC3 is the largest subunit of the activating signal co-integrator complex (ASCC), and its DNA unwinding activity is required for the AlkBH3/ASCC-dependent DNA de-alkylation repair pathway. Here, the authors identify a minimal stable complex of the two ASCC subunits ASCC2 and ASCC3, determine the complex crystal structure and further show that cancer-related mutations at the interface between both proteins reduce ASCC2–ASCC3 affinity.

    • Junqiao Jia
    • Eva Absmeier
    • Markus C. Wahl
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Quantum dots sequentially loaded into cells are used to generate barcodes that can identify thousands of individual cells within a population and that can be used to track cells over many hours.

    • Paul Rees
    • John W Wills
    • Huw D Summers
    Research
    Nature Methods
    Volume: 11, P: 1177-1181

  • It remains poorly understood how a single RNA-binding protein recognizes diverse RNA targets. Here the authors use an integrative approach to study the binding of spliceosomal SNF protein to U1 and U2 small nuclear RNAs in the presence or absence of auxiliary protein U2A’ and show how SNF’s conformational dynamics are tuned to recognize different stem-loop structures.

    • Gert Weber
    • Gregory T. DeKoster
    • Markus C. Wahl
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Diacylglycerol kinase is a small bacterial membrane-bound trimer that catalyses diacylglycerol conversion to phosphatidic acid. Here, the authors solve the crystal structure of the kinase bound to a lipid substrate and an ATP analogue, and show that the active site arose through convergent evolution.

    • Dianfan Li
    • Phillip J. Stansfeld
    • Martin Caffrey
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • Through the use of a reversible chemical dimerizer, the splicing factor PRPF38A is re-localized to the nuclear lamina, paving the way for a systematic analysis of spatio-temporal splicing regulation.

    • Karen Vester
    • Marco Preußner
    • Markus C. Wahl
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-14