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Showing 1–5 of 5 results
Advanced filters: Author: Nicoletta Caronni Clear advanced filters

  • Acquisition of dying tumor cell-associated antigens is an essential step for the initiation of anti-tumor immune response by conventional type 1 dendritic cells (cDC1). Here the authors show that the loss of TIM4 expression in lung tumor associated cDC1 is associated with less efficient uptake of cell associated antigens and reduction of CD8 + T cell activation in advanced lung tumors.

    • Nicoletta Caronni
    • Giulia Maria Piperno
    • Federica Benvenuti
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Single-cell and spatial gene expression analyses of pancreatic ductal adenocarcinoma uncover a population of interleukin-1β-expressing macrophages that drive inflammatory reprogramming of neighboring tumour cells leading to disease progression and poor prognosis for patients.

    • Nicoletta Caronni
    • Federica La Terza
    • Renato Ostuni
    Research
    Nature
    Volume: 623, P: 415-422

  • The atypical chemokine receptor ACKR2 regulates immune responses. Here the authors confirm that ACKR2 depletion promotes primary tumor growth but show it has an anti-metastatic effect in mouse models of breast cancer by affecting myeloid differentiation and unleashing the anti-metastatic activity of neutrophils.

    • Matteo Massara
    • Ornella Bonavita
    • Raffaella Bonecchi
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Recent studies suggest that neutrophils can exhibit substantial function diversity. Here, Ostuni and colleagues perform immunophenotyping and transcriptome analysis to characterize the heterogeneity of human neutrophils, both under steady state and upon stress-induced conditions.

    • Elisa Montaldo
    • Eleonora Lusito
    • Renato Ostuni
    Research
    Nature Immunology
    Volume: 23, P: 1470-1483

  • Response to immune checkpoint inhibitors (ICIs) in patients with non-small cell lung cancer (NSCLC) remains suboptimal, even for tumors with elevated tumor mutational burden. Here the authors generate a model of NSCLC with enhanced mutational load, showing that, while still resistant to ICIs, hypermutated tumors become sensitive to dendritic cell-targeted therapy.

    • Lucía López
    • Luciano Gastón Morosi
    • Federica Benvenuti
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17