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Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients

The mechanisms that shape the regulatory T cell repertoire in patients with cancer are not completely understood. Here, the authors observe that, in breast cancer patients, tumor-resident regulatory T cells do not show clonal relationship with their circulating counterpart, but share a common origin with intratumoral antigen-experienced conventional T cells.

Maria Xydia
Raheleh Rahbari
Philipp Beckhove
ResearchOpen Access18 Feb 2021
Nature Communications

Volume: 12, P: 1-18
Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity

It has been increasingly recognised that tumours are not made up of a homogeneous population of cells. Here, the authors show heterogeneous expression of five protein markers in renal cell cancer and demonstrate that the progression of the tumour does not influence the degree of heterogeneity in the tumour.

Rouven Hoefflin
Bernd Lahrmann
Stefan Duensing
ResearchOpen Access13 Jun 2016
Nature Communications

Volume: 7, P: 1-12
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Genome-wide association studies (GWAS) have become a key tool to discover genetic markers for complex traits; however, environmental factors that interact with genes are rarely considered. Here, the authors conduct a GWAS of obesity traits, and find that smoking may alter genetic susceptibilities.

Anne E. Justice
Thomas W. Winkler
L Adrienne Cupples
ResearchOpen Access26 Apr 2017
Nature Communications

Volume: 8, P: 1-19
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice

Genetic inactivation of VHL leads to stabilization of HIF-1α/HIF-2α and is associated with clear cell renal cell carcinoma (ccRCC) initiation and progression. Using an autochthonous mouse model of ccRCC with Vhl deletion, here the authors show that HIF-1α is necessary for tumor formation, while HIF-2α deletion has only a moderate effect.

Rouven Hoefflin
Sabine Harlander
Ian J. Frew
ResearchOpen Access17 Aug 2020
Nature Communications

Volume: 11, P: 1-21
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index. Gene-based meta-analysis and functional studies implicate 13 genes, eight of which are novel, and neuronal pathways as factors in human obesity.

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Research22 Dec 2017
Nature Genetics

Volume: 50, P: 26-41
A molecular mechanotransduction pathway regulates collective migration of epithelial cells

Spatz and colleagues report that intercellular pulling forces between leader and follower cells in migrating epithelial sheets regulate merlin subcellular localization and the crosstalk between merlin and Rac1 to promote collective cell migration.

Tamal Das
Kai Safferling
Joachim P. Spatz
Research23 Feb 2015
Nature Cell Biology

Volume: 17, P: 276-287
A 3D self-organizing multicellular epidermis model of barrier formation and hydration with realistic cell morphology based on EPISIM

Thomas Sütterlin
Erika Tsingos
Niels Grabe
ResearchOpen Access06 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease

Filippo Martinelli
Almut Heinken
Ines Thiele
ResearchOpen Access13 Mar 2024
Scientific Reports

Volume: 14, P: 1-14
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections03 Jun 2019
Nature Genetics

Volume: 51, P: 1191-1192
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections16 Mar 2018
Nature Genetics

Volume: 50, P: 766-767
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections16 Mar 2018
Nature Genetics

Volume: 50, P: 765-766
Correlation between genomic index lesions and mpMRI and ⁶⁸Ga-PSMA-PET/CT imaging features in primary prostate cancer

Claudia Kesch
Jan-Philipp Radtke
Stefan Duensing
ResearchOpen Access12 Nov 2018
Scientific Reports

Volume: 8, P: 1-8
High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer

Pauline L. Pfuderer
Alexej Ballhausen
Aysel Ahadova
ResearchOpen Access30 Jul 2019
British Journal of Cancer

Volume: 121, P: 395-404
Quantitative diagnosis of breast tumors by morphometric classification of microenvironmental myoepithelial cells using a machine learning approach

Yoichiro Yamamoto
Akira Saito
Niels Grabe
ResearchOpen Access25 Apr 2017
Scientific Reports

Volume: 7, P: 1-12
Author Correction: Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease

Filippo Martinelli
Almut Heinken
Ines Thiele
Amendments and CorrectionsOpen Access12 Nov 2024
Scientific Reports

Volume: 14, P: 1

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