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Composite SMG5-SMG6 PIN domain formation is essential for NMD

Execution of mRNA cleavage in nonsense-mediated decay remained elusive. The authors show that SMG5 complements SMG6 to form a highly active, composite endonuclease with expanded catalytic center that enables regulated substrate cleavage.

Katharina Kurscheidt
Sophie Theunissen
Niels H. Gehring
ResearchOpen Access19 Feb 2026
Nature Communications

Volume: 17, P: 1-15
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity

Degradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly independent pathways, SMG6-mediated endonucleolytic cleavage and/or SMG5-SMG7-induced accelerated deadenylation. Here the authors show that SMG5-SMG7 maintain NMD activity by permitting SMG6 activation.

Volker Boehm
Sabrina Kueckelmann
Niels H. Gehring
ResearchOpen Access25 Jun 2021
Nature Communications

Volume: 12, P: 1-19
Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences

Degradation of messenger RNA is a key regulatory step in controlling eukaryotic gene expression. Here the authors present xrFrag, a molecular tool to interrogate the extent and directionality of mRNA turnover by the detection of stabilized decay intermediates produced by several common decay pathways.

Volker Boehm
Jennifer V. Gerbracht
Niels H. Gehring
ResearchOpen Access05 Dec 2016
Nature Communications

Volume: 7, P: 1-15
ER-associated RNA silencing promotes ER quality control

Efstathiou et al. describe an Argonaute-dependent endoplasmic reticulum (ER)-associated RNA silencing pathway that acts together with ER-associated protein degradation to preserve ER homeostasis and function.

Sotirios Efstathiou
Franziska Ottens
Thorsten Hoppe
ResearchOpen Access05 Dec 2022
Nature Cell Biology

Volume: 24, P: 1714-1725
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Bin Zhou
Kate E. Sheffer
Majid Ezzati
ResearchOpen Access09 Nov 2023
Nature Medicine

Volume: 29, P: 2885-2901
Increased efficiency of mRNA 3′ end formation: a new genetic mechanism contributing to hereditary thrombophilia

Niels H. Gehring
Ute Frede
Andreas E. Kulozik
Research09 Jul 2001
Nature Genetics

Volume: 28, P: 389-392
Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain

The cellular functions of poly-SUMO chains of different compositions are not fully understood. Here, the authors characterize Arkadia/RNF111 as a SUMO-targeted ubiquitin ligase that recognizes proteins with hybrid SUMO1-capped SUMO2/3 chains and targets them for proteasomal degradation.

Annie M. Sriramachandran
Katrin Meyer-Teschendorf
R. Jürgen Dohmen
ResearchOpen Access15 Aug 2019
Nature Communications

Volume: 10, P: 1-12
Detection and quantification of RNA decay intermediates using XRN1-resistant reporter transcripts

This protocol is used to detect RNA decay intermediates in human cultured cells. Reporter mRNAs can be detected and quantified with molecular biology (northern blot, qPCR) and single-molecule fluorescence microscopy (smFISH, live imaging) approaches.

Franka Voigt
Jennifer V. Gerbracht
Niels H. Gehring
Protocols24 Apr 2019
Nature Protocols

Volume: 14, P: 1603-1633
Harnessing short poly(A)-binding protein-interacting peptides for the suppression of nonsense-mediated mRNA decay

Tobias Fatscher
Niels H. Gehring
ResearchOpen Access22 Nov 2016
Scientific Reports

Volume: 6, P: 1-12
Plasmid transfection influences the readout of nonsense-mediated mRNA decay reporter assays in human cells

Jennifer V. Gerbracht
Volker Boehm
Niels H. Gehring
ResearchOpen Access06 Sept 2017
Scientific Reports

Volume: 7, P: 1-8
The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif

Marc Lewitzky
Christian Kardinal
Stephan M Feller
Research09 Apr 2001
Oncogene

Volume: 20, P: 1052-1062

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