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Advanced filters: Author: Nien-Shin Shih Clear advanced filters

  • IL-22 induces IL-18 expression by intestinal epithelial cells. Authors show here that IL-18 is a key barrier maintenance factor during adherent-invasive E. coli invasion, inducing expression of anti-microbial genes in Paneth cells via Stat3, prompting IFNγ expression in T cells and triggering intestinal Lgr5+ stem cell expansion via Tcf4.

    • Hung-Yu Chiang
    • Hsueh-Han Lu
    • Jr-Wen Shui
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19