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Showing 1–4 of 4 results
Advanced filters: Author: Nigel C. Brissett Clear advanced filters

  • PrimPol is a multifunctional replicative enzyme that can bypass DNA damage, as well as reprime replication restart. Here, the authors have elucidated how PrimPol is recruited to stalled replication forks via specific interactions with RPA, which stimulates its primase activity.

    • Thomas A. Guilliam
    • Nigel C. Brissett
    • Aidan J. Doherty
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Ligase D is a conserved DNA repair protein complex that repairs double-strand breaks in stationary phase prokaryotes. Here the authors show that orthologous Ligase C has a role in base excision repair during stationary phase.

    • Przemysław Płociński
    • Nigel C. Brissett
    • Aidan J. Doherty
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.

    • Nigel C. Brissett
    • Katerina Zabrady
    • Aidan J. Doherty
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Crystal structures of human and prokaryotic ribosomal oxygenases reported here, with and without their ribosomal protein substrates, support their assignments as hydroxylases, and provide insights into the evolution of the JmjC-domain-containing hydroxylases and demethylases.

    • Rasheduzzaman Chowdhury
    • Rok Sekirnik
    • Christopher J. Schofield
    Research
    Nature
    Volume: 510, P: 422-426