Nature Search

The control of microvascular permeability and blood pressure by neutral endopeptidase

Bao Lu
Michela Figini
Nigel Bunnett
Research01 Aug 1997
Nature Medicine

Volume: 3, P: 904-907
Targeting prostaglandin E₂ receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation

Non-steroidal anti-inflammatory drugs (NSAIDs) are known to alleviate pain by reducing inflammation. To the contrary, here, the authors show that selective inhibition of the prostaglandin E2 receptor (EP2) in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation.

Romina Nassini
Lorenzo Landini
Pierangelo Geppetti
ResearchOpen Access25 Sept 2025
Nature Communications

Volume: 16, P: 1-19
TGR5 agonists induce peripheral and central hypersensitivity to bladder distension

Ashlee Caldwell
Luke Grundy
Stuart M. Brierley
ResearchOpen Access15 Jun 2022
Scientific Reports

Volume: 12, P: 1-19
Probing the activity of cysteine cathepsins in inflammatory bowel diseases

Bethany M. Anderson
Alexander R. Ziegler
Laura E. Edgington-Mitchell
ResearchOpen Access23 Dec 2025
Scientific Reports

Volume: 16, P: 1-17
Myosin VI drives arrestin-independent internalization and signaling of GPCRs

G-protein coupled receptors (GPCRs) regulate numerous physiological processes and are a prominent therapeutic target. Here, Patel et al. delineate a β-arrestin independent pathway, driven by myosin VI, to shape GPCR trafficking and signaling.

Nishaben M. Patel
Léa Ripoll
Sivaraj Sivaramakrishnan
ResearchOpen Access06 Dec 2024
Nature Communications

Volume: 15, P: 1-15
Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice

The mechanism of CGRP-evoked peripheral pain is unclear. Here, the authors show that the CGRP-mediated neuronal/Schwann cell pathway mediates allodynia associated with neurogenic inflammation, contributing to the algesic action of CGRP in mice.

Francesco De Logu
Romina Nassini
Pierangelo Geppetti
ResearchOpen Access03 Feb 2022
Nature Communications

Volume: 13, P: 1-19
A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

A pH-responsive, soft polymeric nanoparticle targets the neurokinin 1 receptor in acidified endosomes to inhibit signalling events leading to chronic pain.

Paulina D. Ramírez-García
Jeffri S. Retamal
Nigel W. Bunnett
Research04 Nov 2019
Nature Nanotechnology

Volume: 14, P: 1150-1159
Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice

Following peripheral nerve injury, influx of immune cells to the site may contribute to the development of chronic pain. Here the authors show that TRPA1 is expressed on Schwann cells and contributes to immune cell influx in a mouse model of neuropathic pain.

Francesco De Logu
Romina Nassini
Pierangelo Geppetti
ResearchOpen Access01 Dec 2017
Nature Communications

Volume: 8, P: 1-16
Oral cancer induced TRPV1 sensitization is mediated by PAR₂ signaling in primary afferent neurons innervating the cancer microenvironment

Nicole N. Scheff
Ian M. Wall
Brian L. Schmidt
ResearchOpen Access08 Mar 2022
Scientific Reports

Volume: 12, P: 1-14
Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice

Serotonin (5-HT) is an important mediator of tissue edema and inflammation. The authors used mouse models and cell-based signaling assays to provide greater understanding of the mechanisms involved. They demonstrate that effects of 5-HT are mediated through the 5-HT_2A receptor and involve activation of the mechanosensitive ion channel TRPV4 and neuropeptide release.

Jeffri S. Retamal
Megan S. Grace
Peter McIntyre
Research15 Apr 2021
Laboratory Investigation

Volume: 101, P: 851-864
Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease

Bethany M. Anderson
Daniel P. Poole
Laura E. Edgington-Mitchell
ResearchOpen Access16 Sept 2019
Scientific Reports

Volume: 9, P: 1-12
Neurotensin-induced miR-133α expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin

Ivy Ka Man Law
Dane Jensen
Charalabos Pothoulakis
ResearchOpen Access23 Feb 2016
Scientific Reports

Volume: 6, P: 1-14
The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability

The thrombin receptor PAR1 and mechanosensitve ion channel TRPV4 are known to modulate endothelial barriers and contribute to edema, but functional interactions between these targets are not well understood. Utilizing cell signalling studies and in vivo models, the authors have demonstrated that PAR1 activation leads to functional upregulation of endothelial TRPV4 activity, to promote vascular leakage in airways and the gastrointestinal system.

Scott Peng
Megan S. Grace
Peter McIntyre
Research27 Apr 2020
Laboratory Investigation

Volume: 100, P: 1057-1067

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