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Showing 1–8 of 8 results
Advanced filters: Author: Nigil Haroon Clear advanced filters

  • The mechanisms underlying the genetic association between HLA-B27 and ankylosing spondylitis, including the contribution of endoplasmic reticulum aminopeptidase 1 (ERAP1), continue to elude the field. New findings support the involvement of the unfolded protein response and highlight the therapeutic potential and limitations of targeting ERAP1 in this disease.

    • Nigil Haroon
    • Robert D. Inman
    News & Views
    Nature Reviews Rheumatology
    Volume: 19, P: 134-135

  • The authors present the case of a 49-year-old man diagnosed with chronic unilateral sacroiliitis who did not respond to conventional therapy with corticosteroids and NSAIDs. A single intra-articular injection of the tumor necrosis factor inhibitor infliximab resulted in gradual and steady improvements in pain, stiffness and inflammation.

    • Finbar D O'Shea
    • Nigil Haroon
    • Robert D Inman
    Reviews
    Nature Reviews Rheumatology
    Volume: 5, P: 171-173

  • In this Review, the authors discuss the latest insights into the genetic associations and pathological mechanisms of ankylosing spondylitis, in particular HLA-B27-mediated pathology, antigen-presentation pathways and the role of type 3 immunity.

    • Vidya Ranganathan
    • Eric Gracey
    • Nigil Haroon
    Reviews
    Nature Reviews Rheumatology
    Volume: 13, P: 359-367

  • Several studies have shown that the gene encoding endoplasmic reticulum aminopeptidase 1 (ERAP1) is associated with ankylosing spondylitis (AS). ERAP1 and the closely related ERAP2 are involved in trimming peptides within the endoplasmic reticulum for loading onto major histocompatibility complex molecules; ERAP1 also has a role in releasing some membrane-bound cytokine receptors. The potential contributions of these aminopeptidases to the pathogenesis of AS are outlined in this Review.

    • Nigil Haroon
    • Robert D. Inman
    Reviews
    Nature Reviews Rheumatology
    Volume: 6, P: 461-467

  • Ankylosing spondylitis is a common, highly inheritable inflammatory arthritis with poorly understood biology. Here Brown, Cortes and colleagues use fine mapping of the major histocompatibility complex and identify novel associations, and identify other HLA alleles that like HLA-B27 interact with ERAP1 variants to influence disease risk.

    • Adrian Cortes
    • Sara L. Pulit
    • Matthew A. Brown
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • Matthew Brown and colleagues identify multiple susceptibility variants for ankylosing spondylitis through an association study based on high-density genotyping of immune-related loci. Their findings implicate numerous biological pathways in the pathogenesis of this disease and highlight shared risk factors with other autoimmune diseases.

    • Adrian Cortes
    • Johanna Hadler
    • Matthew A Brown
    Research
    Nature Genetics
    Volume: 45, P: 730-738

  • Axial disease occurs in psoriatic arthritis (PsA) and ankylosing spondylitis, but questions remain over whether axial PsA is a distinct disease. In this Review, the authors address the current state of knowledge concerning axial PsA and propose a research agenda.

    • Joy Feld
    • Vinod Chandran
    • Dafna Gladman
    Reviews
    Nature Reviews Rheumatology
    Volume: 14, P: 363-371