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Showing 1–4 of 4 results

Advanced filters: Author: Nikita Dsouza Clear advanced filters

Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Etv2 regulates enhancer chromatin status to initiate Shh expression in the limb bud

The embryonic limb bud is known to be patterned by a Shh morphogen gradient, though how Shh expression is activated remains less clear. Here the authors show that Etv2 acts as a pioneer transcription factor to mediate accessibility of the ZRS enhancer and initiate Shh expression.

Naoko Koyano-Nakagawa
Wuming Gong
Daniel J. Garry
ResearchOpen Access21 Jul 2022
Nature Communications

Volume: 13, P: 1-17
ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage

Gong et al. report that ETV2 functions as a pioneer factor that remodels chromatin and regulates endothelial genes, thus providing a mechanism of endothelial development with potential therapeutic applications.

Wuming Gong
Satyabrata Das
Daniel J. Garry
Research12 May 2022
Nature Cell Biology

Volume: 24, P: 672-684
Defining the genotypic and phenotypic spectrum of X-linked MSL3-related disorder

Theresa Brunet
Kirsty McWalter
Matias Wagner
ResearchOpen Access11 Nov 2020
Genetics in Medicine

Volume: 23, P: 384-395