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Showing 1–6 of 6 results
Advanced filters: Author: Niklas Freund Clear advanced filters

  • Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.

    • Nitsan Goldstein
    • Amadeus Maes
    • J. Nicholas Betley
    ResearchOpen Access
    Nature
    Volume: 647, P: 689-697

  • The authors previously developed a mouse model ABab-A2 transduced with complete human TCR gene loci and HLA-A*02:01, termed ABab-A2 mice. Here the authors introduce a complete HLA-I haplotype into ABab-A2 mice and make the ABab-I mice, which manifest higher peripheral CD8 counts, broader TCR repertoire and stronger epitope response compared to ABab-A2 mice.

    • Arunraj Dhamodaran
    • Xiaojing Chen
    • Thomas Blankenstein
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Epitope tags are widely used in various applications, but often lack versatility. Here, the authors introduce a small, alpha helical tag, which is recognized by a high affinity nanobody and can be used in a range of different applications, from protein purification to super-resolution imaging and in vivo detection of proteins.

    • Hansjörg Götzke
    • Markus Kilisch
    • Steffen Frey
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Pro-inflammatory signals trigger innate immune pathways with consequential metabolic remodeling. Here authors show that a rate-limiting enzymes of glycolysis, PFKL, is directly regulated by innate stimuli via phosphorylation at Ser775, which modification in turn influences pro-inflammatory cytokine production.

    • Meiyue Wang
    • Heinrich Flaswinkel
    • Veit Hornung
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Sterically demanding 2′-modified nucleotides used in antisense therapeutics have thus far been challenging to synthesise enzymatically. Now, it has been shown that mutation of two gatekeeper residues in an archaeal DNA polymerase unlocks efficient synthesis of the modified nucleic acid oligomers 2′-O-methyl-RNA and 2′-O-(2-methoxyethyl)-RNA and enables the evolution of 2′-O-methyl-RNA enzymes.

    • Niklas Freund
    • Alexander I. Taylor
    • Philipp Holliger
    Research
    Nature Chemistry
    Volume: 15, P: 91-100