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Showing 1–3 of 3 results
Advanced filters: Author: Nikolai Lorenzen Clear advanced filters

  • pH is a critical regulator of (bio)chemical processes and therefore tightly regulated in nature. Now, proteins have been shown to possess the functionality to drive pH gradients without requiring energy input or membrane enclosure but through condensation. Protein condensates can drive unique pH gradients that modulate biochemical activity in both living and artificial systems.

    • Hannes Ausserwöger
    • Rob Scrutton
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Chemistry
    Volume: 18, P: 246-257

  • Antibodies find key applications in research, diagnostics, and therapeutics, but their development can be impeded by poor stability or solubility. Here the authors developed a computational strategy that enables antibody optimisation, without affecting functionality.

    • Angelo Rosace
    • Anja Bennett
    • Pietro Sormanni
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • While antibodies have a remarkable track record in therapeutics, achieving sufficient specificity remains an issue. This Review discusses the physicochemistry of non-specificity, with a focus on surface patches as a key challenge, and outlines future opportunities to improve protein binding.

    • Hannes Ausserwöger
    • Matthias M. Schneider
    • Nikolai Lorenzen
    Reviews
    Nature Reviews Chemistry
    Volume: 6, P: 844-861