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Designing and interpreting 4D tumour spheroid experiments

Tumour spheroid experiments with real-time fluorescent ubiquitination-based cell cycle imaging are interpreted using mathematical modelling and statistical identifiability analysis. A framework is provided to compare data obtained across different experimental designs and the experimental design choices that provide reliable biological insight are revealed.

Ryan J. Murphy
Alexander P. Browning
Matthew J. Simpson
ResearchOpen Access24 Jan 2022
Communications Biology

Volume: 5, P: 1-11
Compression-dependent microtubule reinforcement enables cells to navigate confined environments

Ju et al. show that during three-dimensional cell migration, compression recruits cytoplasmic linker-associated proteins to microtubules; these stabilized microtubules then coordinate nuclear positioning and contractility in confined migration.

Robert J. Ju
Alistair D. Falconer
Samantha J. Stehbens
Research19 Aug 2024
Nature Cell Biology

Volume: 26, P: 1520-1534
Persister state-directed transitioning and vulnerability in melanoma

Slow-cycling melanoma persister cells are characterised by a high, reversible expression of H3K4 demethylase KDM5B. Here, the authors use genetic and chemical methods to enforce a permanent high expression of KDM5B and show that these cells transit to a melanocytic differentiated state and undergo cell cycle arrest.

Heike Chauvistré
Batool Shannan
Alexander Roesch
ResearchOpen Access01 Jun 2022
Nature Communications

Volume: 13, P: 1-17
Head and neck cancer patient-derived tumouroid cultures: opportunities and challenges

B. W. M. Thilini J. Basnayake
Paul Leo
Chamindie Punyadeera
ReviewsOpen Access10 Feb 2023
British Journal of Cancer

Volume: 128, P: 1807-1818
The clinically relevant MEK inhibitor mirdametinib combined with D-cycloserine and prediction error disrupts fear memory in PTSD models

Sanket B. Raut
Fanny Joly
Luke R. Johnson
ResearchOpen Access18 Dec 2024
Translational Psychiatry

Volume: 14, P: 1-16
BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

Erinna F. Lee
Tiffany J. Harris
W. Douglas Fairlie
ResearchOpen Access24 Apr 2019
Cell Death & Disease

Volume: 10, P: 1-14

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Designing and interpreting 4D tumour spheroid experiments

Compression-dependent microtubule reinforcement enables cells to navigate confined environments

Persister state-directed transitioning and vulnerability in melanoma

Head and neck cancer patient-derived tumouroid cultures: opportunities and challenges

The clinically relevant MEK inhibitor mirdametinib combined with D-cycloserine and prediction error disrupts fear memory in PTSD models

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

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