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Showing 1–4 of 4 results
Advanced filters: Author: Nikolay Dobrev Clear advanced filters

  • The human PAXT complex and the MTREC complex in fission yeast are important exosome cofactors, serving in the degradation of specific noncoding RNAs. Here, the authors combine structural, biochemical and in vivo methods to show how Red1 recruits the Mtl1 helicase by an interface not seen before in helicase-adaptor complexes.

    • Nikolay Dobrev
    • Yasar Luqman Ahmed
    • Irmgard Sinning
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Here, the authors isolate several nanobodies from a synthetic library that bind the receptor-binding domain (RBD) of SARS-CoV-2 spike protein (S) and neutralize S pseudotyped viruses. Cryo-EM structure of Spike with one nanobody and further biophysical analysis shows competition with ACE2 binding.

    • Tânia F. Custódio
    • Hrishikesh Das
    • Christian Löw
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • The Braun lab shows that the conserved nuclear membrane protein Lem2 interacts with the MTREC complex of the nuclear-exosome pathway to promote recruitment and degradation of ncRNAs and meiotic transcripts at the nuclear periphery in Schizosaccharomyces pombe.

    • Lucía Martín Caballero
    • Matías Capella
    • Sigurd Braun
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 910-921