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Showing 1–5 of 5 results
Advanced filters: Author: Nikolche Gjorevski Clear advanced filters

  • In this work, authors develop a “mini-bladder” model with a perfusable lumen that reveals how urine and its solute composition impact tissue resilience and enables cell-wall-deficient uropathogenic Escherichia coli to persist in tissues and drive recurrence in urinary tract infections.

    • Gauri Paduthol
    • Mikhail Nikolaev
    • John D. McKinney
    ResearchOpen Access
    Nature Communications
    P: 1-17

  • We combined human intestinal immuno-organoids and single-cell transcriptomics to investigate intestinal inflammation triggered by cancer-targeting biologics, which was associated with an activated population of CD8+ T cells that progressively acquired intraepithelial and cytotoxic features.

    • Timothy Recaldin
    • Linda Steinacher
    • Nikolche Gjorevski
    ResearchOpen Access
    Nature
    Volume: 633, P: 165-173

  • Patient-derived intestinal organoids and tumouroids supplemented with immune cells can be used to predict and study the on-target off-tumour toxicities of T-cell-engaging bispecific antibodies and to capture inter-patient variabilities in the responses to the antibodies.

    • Marius F. Harter
    • Timothy Recaldin
    • Nikolche Gjorevski
    ResearchOpen Access
    Nature Biomedical Engineering
    Volume: 8, P: 345-360

  • The human endoderm-derived organoid cell atlas (HEOCA) presents an integrative analysis of single-cell transcriptomes across different conditions, sources and protocols. It compares cell types and states between models, and harmonizes cell annotations through mapping to primary tissues.

    • Quan Xu
    • Lennard Halle
    • J. Gray Camp
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 1201-1212

  • Recreating human immune biology poses a grand challenge owing to its unique complexity and diversity. This Review discusses advances in bioengineering lymphoid and mucosal tissues, with an emphasis on their translational value.

    • Yale S. Michaels
    • Cara F. Buchanan
    • Annie Moisan
    Reviews
    Nature Reviews Bioengineering
    Volume: 1, P: 731-748